ArticleDevelopment (Cambridge, England)2011
Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 79 citations in OpenAlex.
- A framework for identifying transcript orthologs: the evolution of sex bias in alternative transcript structure in Drosophila.bioRxiv : the preprint server for biology · 2026Article
- Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.Cell genomics · 2026Article
- Sex-Specific doublesex Regulation Targeting the Color-Patterning Gene h Underlies the Evolution of Wing Sexual Dimorphism in the Harlequin Ladybug Harmonia axyridis.Evolution & development · 2026Article
- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
- Evolution of sex determination in crustaceans.Marine life science & technology · 2023Review
- Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot.Frontiers in molecular neuroscience · 2023Review
- A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior.Current biology : CB · 2021Article
- Doublesex regulates fruitless expression to promote sexual dimorphism of the gonad stem cell niche.PLoS genetics · 2021Article
- The Sex Determination Cascade in the Silkworm.Genes · 2021Review
- Genome-Wide Profiling of Protein-DNA Interactions with Chromatin Endogenous Cleavage and High-Throughput Sequencing (ChEC-Seq ).Methods in molecular biology (Clifton, N.J.) · 2021Article
- The Hox geneDevelopment (Cambridge, England) · 2019Article
- Doublesex controls specification and maintenance of the gonad stem cell niches inDevelopment (Cambridge, England) · 2019Article
- Article
- Downregulation of female doublesex expression by oral-mediated RNA interference reduces number and fitness of Anopheles gambiae adult females.Parasites & vectors · 2019Article
- Precise staging of beetle horn formation in Trypoxylus dichotomus reveals the pleiotropic roles of doublesex depending on the spatiotemporal developmental contexts.PLoS genetics · 2019Article
- Perturbation of IIS/TOR signaling alters the landscape of sex-differential gene expression in Drosophila.BMC genomics · 2018Article
- The large fraction of heterochromatin in Drosophila neurons is bound by both B-type lamin and HP1a.Epigenetics & chromatin · 2018Article
- Recent advances in understanding the mechanisms of sexually dimorphic plasticity: insights from beetle weapons and future directions.Current opinion in insect science · 2018Review
- Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells.Nucleic acids research · 2017Article
- Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Uncovering the direct regulatory targets of doublesex (dsx) and fruitless (fru) is crucial for an understanding of how they regulate sexual development, morphogenesis, differentiation and adult functions (including behavior) in Drosophila melanogaster. Using a modified DamID approach, we identified 650 DSX-binding regions in the genome from which we then extracted an optimal palindromic 13 bp DSX-binding sequence. This sequence is functional in vivo, and the base identity at each position is important for DSX binding in vitro. In addition, this sequence is enriched in the genomes of D. melanogaster (58 copies versus approximately the three expected from random) and in the 11 other sequenced Drosophila species, as well as in some other Dipterans. Twenty-three genes are associated with both an in vivo peak in DSX binding and an optimal DSX-binding sequence, and thus are almost certainly direct DSX targets. The association of these 23 genes with optimum DSX binding sites was used to examine the evolutionary changes occurring in DSX and its targets in insects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.