ArticleNucleic acids research2011
Structural basis for RNA recognition by NusB and NusE in the initiation of transcription antitermination.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Structure of an internal loop motif with three consecutive U•U mismatches from stem-loop 1 in the 3'-UTR of the SARS-CoV-2 genomic RNA.Nucleic acids research · 2024Article
- Inhibition of bacterial RNA polymerase function and protein-protein interactions: a promising approach for next-generation antibacterial therapeutics.RSC medicinal chemistry · 2024Review
- Early antitermination in the atypical coliphage mEp021 mediated by the Gp17 protein.Archives of virology · 2023Article
- Ligand-Based Drug Design of Novel Antimicrobials againstInternational journal of molecular sciences · 2022Article
- Genome-Wide Association Study of Nucleotide Variants Associated with Resistance to Nine Antimicrobials inMicroorganisms · 2022Article
- Modulators of protein-protein interactions as antimicrobial agents.RSC chemical biology · 2021Review
- In-cell architecture of an actively transcribing-translating expressome.Science (New York, N.Y.) · 2020Article
- Spatial organization of RNA polymerase and its relationship with transcription inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis.Nucleic acids research · 2019Article
- Extrachromosomal Nucleolus-Like Compartmentalization by a Plasmid-Borne Ribosomal RNA Operon and Its Role in Nucleoid Compaction.Frontiers in microbiology · 2018Article
- Small-Molecule Inhibitors of the NusB-NusE Protein-Protein Interaction with Antibiotic Activity.ACS omega · 2017Article
- Structural basis for λN-dependent processive transcription antitermination.Nature microbiology · 2017Article
- Differential regulation of riboflavin supply genes inGut pathogens · 2017Article
- Bacterial Transcription as a Target for Antibacterial Drug Development.Microbiology and molecular biology reviews : MMBR · 2016Review
- HK022 Nun Requires Arginine-Rich Motif Residues Distinct from λ N.Journal of bacteriology · 2015Article
- Bacteriophage lambda: Early pioneer and still relevant.Virology · 2015Review
- Spatial organization of transcription machinery and its segregation from the replisome in fast-growing bacterial cells.Nucleic acids research · 2014Article
- Solution structure of lysine-free (K0) ubiquitin.Protein science : a publication of the Protein Society · 2014Article
- Nus transcription elongation factors and RNase III modulate small ribosome subunit biogenesis in Escherichia coli.Molecular microbiology · 2013Article
- Crystal structure of a plectonemic RNA supercoil.Nature communications · 2012Article
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8 authors.
Funding
Abstract
Processive transcription antitermination requires the assembly of the complete antitermination complex, which is initiated by the formation of the ternary NusB-NusE-BoxA RNA complex. We have elucidated the crystal structure of this complex, demonstrating that the BoxA RNA is composed of 8 nt that are recognized by the NusB-NusE heterodimer. Functional biologic and biophysical data support the structural observations and establish the relative significance of key protein-protein and protein-RNA interactions. Further crystallographic investigation of a NusB-NusE-dsRNA complex reveals a heretofore unobserved dsRNA binding site contiguous with the BoxA binding site. We propose that the observed dsRNA represents BoxB RNA, as both single-stranded BoxA and double-stranded BoxB components are present in the classical lambda antitermination site. Combining these data with known interactions amongst antitermination factors suggests a specific model for the assembly of the complete antitermination complex.
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