ArticleMolecular biology and evolution2011
Long-term balancing selection at the blood group-related gene B4galnt2 in the genus Mus (Rodentia; Muridae).
Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The story of the SdGlycoconjugate journal · 2023Review
- B4galnt2-mediated host glycosylation influences the susceptibility toFrontiers in microbiology · 2022Article
- The Cancer-Associated Antigens Sialyl LewisCancers · 2021Review
- B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen.Xenotransplantation · 2018Review
- Patterns of host gene expression associated with harboring a foregut microbial community.BMC genomics · 2017Article
- Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice.BMC evolutionary biology · 2017Article
- A genome-wide scan for genes under balancing selection in Drosophila melanogaster.BMC evolutionary biology · 2017Article
- Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation.Genome biology and evolution · 2016Article
- Selective sweeps versus introgression - population genetic dynamics of the murine leukemia virus receptor Xpr1 in wild populations of the house mouse (Mus musculus).BMC evolutionary biology · 2015Article
- Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection.PLoS pathogens · 2015Article
- Interspecific introgressive origin of genomic diversity in the house mouse.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Ancestry runs deeper than blood: the evolutionary history of ABO points to cryptic variation of functional importance.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in mice.The ISME journal · 2012Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Recent surveys of the human genome have highlighted the significance of balancing selection in relation to understanding the evolutionary origins of disease-associated variation. Cis-regulatory variation at the blood group-related glycosyltransferase B4galnt2 is associated with a phenotype in mice that closely resembles a common human bleeding disorder, von Willebrand disease. In this study, we have performed a survey of the 5' flanking region of the B4galnt2 gene in several Mus musculus subspecies and Mus spretus. Our results reveal a clear pattern of trans-species polymorphism and indicate that allele classes conferring alternative tissue-specific expression patterns have been maintained for >2.8 My in the genus Mus. Furthermore, analysis of B4galnt2 expression patterns revealed the presence of an additional functional class of alleles, supporting a role for gastrointestinal phenotypes in the long-term maintenance of expression variation at this gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.