ArticleMolecular microbiology2011
Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Article
- Staphylococcus aureus adapts to the host nutritional environment by coordinating the activity of central metabolic enzymes.PLoS pathogens · 2026Article
- Article
- Review
- Detection of virulence factors in opportunistic bacteria: advances, challenges, and practical implementation.Frontiers in microbiology · 2025Review
- Article
- Quorum-sensingeLife · 2024Article
- Quorum-sensingbioRxiv : the preprint server for biology · 2024Article
- Article
- The major role ofVirulence · 2023Article
- Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching.PLoS pathogens · 2023Article
- Transcription-replication interactions reveal principles of bacterial genome regulation.Research square · 2023Article
- Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching.bioRxiv : the preprint server for biology · 2023Article
- Multiple Domains of Staphylococcal Superantigen-like Protein 11 (SSL11) Contribute to Neutrophil Inhibition.Biochemistry · 2022Article
- Observational
- Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens.Science advances · 2021Article
- Salicylic acid stabilizes Staphylococcus aureus biofilm by impairing the agr quorum-sensing system.Scientific reports · 2021Article
- Waddington's Landscapes in the Bacterial World.Frontiers in microbiology · 2021Review
- Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies.Microbiology and molecular biology reviews : MMBR · 2020Review
- Regulation of the Staphylococcal Superantigen-Like Protein 1 Gene of Community-Associated Methicillin-ResistantToxins · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
Staphylococcus aureus overproduces a subset of immunomodulatory proteins known as the staphylococcal superantigen-like proteins (Ssls) under conditions of pore-mediated membrane stress. In this study we demonstrate that overproduction of Ssls during membrane stress is due to the impaired activation of the two-component module of the quorum-sensing accessory gene regulator (Agr) system. Agr-dependent repression of ssl expression is indirect and mediated by the transcription factor repressor of toxins (Rot). Surprisingly, we observed that Rot directly interacts with and activates the ssl promoters. The role of Agr and Rot as regulators of ssl expression was observed across several clinically relevant strains, suggesting that overproduction of immunomodulatory proteins benefits agr-defective strains. In support of this notion, we demonstrate that Ssls contribute to the residual virulence of S. aureus lacking agr in a murine model of systemic infection. Altogether, these results suggest that S. aureus compensates for the inactivation of Agr by producing immunomodulatory exoproteins that could protect the bacterium from host-mediated clearance.
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