ArticleLangmuir : the ACS journal of surfaces and colloids2011
On the low surface tension of lung surfactant.
Article in Langmuir : the ACS journal of surfaces and colloids, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 108 citations in OpenAlex.
- Comparative biophysical study of clinical surfactants using constrained drop surfactometry.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Phase transitions of the pulmonary surfactant film at the perfluorocarbon-water interface.Biophysical journal · 2023Article
- Polymer Lung Surfactants Attenuate Direct Lung Injury in Mice.ACS biomaterials science & engineering · 2023Article
- Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein-Lipid Interactions.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Biophysical analysis of gelatin and PLGA nanoparticle interactions with complex biomimetic lung surfactant models.RSC advances · 2022Article
- Pulmonary surfactant and COVID-19: A new synthesis.QRB discovery · 2022Article
- E-cigarette aerosol exposure of pulmonary surfactant impairs its surface tension reducing function.PloS one · 2022Article
- Shape matters-the interaction of gold nanoparticles with model lung surfactant monolayers.Journal of the Royal Society, Interface · 2021Article
- Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- Atomic Force Microscopy Imaging of Adsorbed Pulmonary Surfactant Films.Biophysical journal · 2020Article
- In vitro characterization and in vivo comparison of the pulmonary outcomes of Poractant alfa and Calsurf in ventilated preterm rabbits.PloS one · 2020Article
- Tracheal acid or surfactant instillation raises alveolar surface tension.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Role of Surface Tension in Gas Nanobubble Stability Under Ultrasound.ACS applied materials & interfaces · 2018Article
- Electronic cigarette vapor alters the lateral structure but not tensiometric properties of calf lung surfactant.Respiratory research · 2017Article
- On the Morphology of the SDS Film on the Surface of Borosilicate Glass.Materials (Basel, Switzerland) · 2017Article
- Article
- Phase Transitions in Dipalmitoylphosphatidylcholine Monolayers.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Automated Droplet Manipulation Using Closed-Loop Axisymmetric Drop Shape Analysis.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Tensiometric and Phase Domain Behavior of Lung Surfactant on Mucus-like Viscoelastic Hydrogels.ACS applied materials & interfaces · 2016Article
- Calf Lung Surfactant Recovers Surface Functionality After Exposure to Aerosols Containing Polymeric Particles.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Natural lung surfactant contains less than 40% disaturated phospholipids, mainly dipalmitoylphosphatidylcholine (DPPC). The mechanism by which lung surfactant achieves very low near-zero surface tensions, well below its equilibrium value, is not fully understood. To date, the low surface tension of lung surfactant is usually explained by a squeeze-out model which predicts that upon film compression non-DPPC components are gradually excluded from the air-water interface into a surface-associated surfactant reservoir. However, detailed experimental evidence of the squeeze-out within the physiologically relevant high surface pressure range is still lacking. In the present work, we studied four animal-derived clinical surfactant preparations, including Survanta, Curosurf, Infasurf, and BLES. By comparing compression isotherms and lateral structures of these surfactant films obtained by atomic force microscopy within the physiologically relevant high surface pressure range, we have derived an updated squeeze-out model. Our model suggests that the squeeze-out originates from fluid phases of a phase-separated monolayer. The squeeze-out process follows a nucleation-growth model and only occurs within a narrow surface pressure range around the equilibrium spreading pressure of lung surfactant. After the squeeze-out, three-dimensional nuclei stop growing, thereby resulting in a DPPC-enriched interfacial monolayer to reduce the air-water surface tension to very low values.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.