Evidence map›Paper›PMID 21650152›Full record

ReviewJournal of natural products2011

The relevance of higher plants in lead compound discovery programs.

A Douglas Kinghorn, Li Pan, Joshua N Fletcher, Heebyung Chai

Abstract readReview
In one paragraph

Review in Journal of natural products, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Assessing the Safety of Carbon Dioxide Extracts ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Antiviral Activity of Medicinal Plant ExtractsPathogens (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Antibacterial Potential ofInternational journal of microbiology · 2025
    Article
  14. International journal of molecular sciences · 2024
    Article
  15. Review
  16. Article
  17. Plants (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Article
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA. kinghorn.4@osu.edu
Li Pan
Joshua N Fletcher
Heebyung Chai

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JAMES R FUCHS · 2007 to 2026
$27.2M
PLANT SELECTION, COLLECTION AND PROJECT DATA MANAGEMENTU19CA052956 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KINGHORN, ALAN DOUGLAS · 1995 to 2004
$4.4M
NONCARIOGENIC INTENSE NATURAL SWEETNERSR01DE008937 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KINGHORN, ALAN DOUGLAS · 1991 to 1993
–
EVALUATION OF NATURAL SWEETENERSR03DE007560 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KINGHORN, ALAN DOUGLAS · 1986 to 1986
–
NOVEL STRATEGIES FOR PLANT-DERIVED ANTICANCER AGENTSU01CA052956 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KINGHORN, ALAN DOUGLAS · 1990 to 1994
–
NCI NIH HHS CA-125066NCI NIH HHS CA-52956NCI NIH HHS P01 CA125066NCI NIH HHS U19 CA052956NIDCR NIH HHS DE-02425NIDCR NIH HHS DE-07560NIDCR NIH HHS DE-08937
6 · The paper itself

Abstract

Along with compounds from terrestrial microorganisms, the constituents of higher plants have provided a substantial number of the natural product-derived drugs used currently in Western medicine. Interest in the elucidation of new structures of the secondary metabolite constituents of plants has remained high among the natural products community over the first decade of the 21st century, particularly of species that are used in systems of traditional medicine or are utilized as botanical dietary supplements. In this review, progress made in the senior author's laboratory in research work on naturally occurring sweeteners and other taste-modifying substances and on potential anticancer agents from tropical plants will be described.

Indexed as

Pharmaceutical PreparationsAntineoplastic Agents, PhytogenicBenzofuransBiological ProductsDietary SupplementsDrug DiscoveryPlants, MedicinalSesquiterpenesTriterpenesAntineoplastic Agents, PhytogenicBenzofuransBiological ProductshernandulcinPharmaceutical PreparationsSesquiterpenessilvestrolTriterpenes

Identifiers

PMID21650152
PMCPMC3158731

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.