Evidence map›Paper›PMID 21649862›Full record

Trial reportActa physiologica (Oxford, England)2011

Effects on blood pressure and autonomic nervous system function of a 12-week exercise or exercise plus DASH-diet intervention in individuals with elevated blood pressure.

K M Edwards, K L Wilson, J Sadja, M G Ziegler, P J Mills

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta physiologica (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

K M EdwardsUniversity of Sydney, Exercise Health and Performance Research Group, Lidcombe, Australia. kate.edwards@sydney.edu.au
K L Wilson
J Sadja
M G Ziegler
P J Mills
University of California, San Diego · USUniversity of Sydney · AU

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2010
$74.3M
BNP and Neuroimmune Characteristics of CHF &DepressionR01HL073355 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLS, PAUL J · 2005 to 2014
$5.6M
SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESIONR01HL057265 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLS, PAUL J · 1997 to 2010
$3.9M
NCRR NIH HHS M01 RR000827NCRR NIH HHS MO1RR-00827NHLBI NIH HHS HL073355NHLBI NIH HHS HL57265-08NHLBI NIH HHS R01 HL057265NHLBI NIH HHS R01 HL073355
6 · The paper itself

Abstract

aimHypertension is related to abnormalities in autonomic nervous system (ANS) function, with increased sympathetic output and decreased parasympathetic tone. Lifestyle interventions are the first line of treatment in hypertension, and decreased blood pressure (BP) effects may be related to changes in ANS function. Using heart rate recovery (HRR) from exercise as an index of parasympathetic tone and plasma noradrenaline as an index of sympathetic tone, we investigated the effects of lifestyle interventions on ANS function in patients with elevated BP.

methodsSedentary participants with elevated BP were randomly assigned to either an exercise only (N = 25), exercise plus dietary approaches to stop hypertension (DASH) diet (N = 12), or waitlist control (N = 15) 12-week intervention. Plasma noradrenaline was measured at rest and participants performed a peak exercise test before and after the intervention. HRR was calculated as peak heart rate (HR) minus HR at 1 min post-exercise.

resultsHeart rate recovery showed a significant group by time interaction; both intervention groups showed increases in HRR from pre- to post-intervention, while waitlist showed no change. Similarly, both exercise plus diet and exercise groups, but not waitlist, showed significant reductions in BP from pre- to post-intervention. Linear regression revealed that BP post-intervention was significantly predicted by change in HRR when controlling for pre-BP, age, gender and BMI.

conclusionsLifestyle interventions induced training-reduced BP and altered autonomic tone, indexed by HRR. This study indicates the importance of behavioural modification in hypertension and that increased parasympathetic function is associated with success in reduction of BP.

Indexed as

Blood PressureExercise TherapyRisk Reduction BehaviorAdultAnalysis of VarianceAutonomic Nervous SystemBiomarkersCaliforniaCombined Modality TherapyExercise TestFemaleHeart RateHumansHypertensionLinear ModelsMaleBiomarkersNorepinephrine

Identifiers

PMID21649862
PMCPMC3192938
OpenAlexW1582209108

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.