Evidence map›Paper›PMID 21649623›Full record

Trial reportJournal of the American Geriatrics Society2011

Effect of a pharmacist-led multicomponent intervention focusing on the medication monitoring phase to prevent potential adverse drug events in nursing homes.

Kate L Lapane, Carmel M Hughes, Lori A Daiello, Kathleen A Cameron, Janice Feinberg

Erratum issuedOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 17 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 17 syntheses or guidelines pooled it, 127 citations in OpenAlex.

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  2. Interventions for preventing falls in older people in care facilities.The Cochrane database of systematic reviews · 2025
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  15. Interventions to optimise prescribing for older people in care homes.The Cochrane database of systematic reviews · 2016
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kate L LapaneDepartment of Epidemiology and Community Health, Virginia Commonwealth University, Richmond, VA 23298, USA. kllapane@vcu.edu
Carmel M Hughes
Lori A Daiello
Kathleen A Cameron
Janice Feinberg
Queen's University Belfast · GBRhode Island Hospital · USVirginia Commonwealth University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031990 · NCRR · VIRGINIA COMMONWEALTH UNIVERSITY · PI CLORE, JOHN N. · 2010 to 2011
$7.7M
Pharmacist Technology for Nursing Home Resident Safety?R18HS011835 · AHRQ · BROWN UNIVERSITY · PI LAPANE, KATE L · 2001 to 2003
–
AHRQ HHS R18 HS011835AHRQ HHS R18 HS 11835-01NCRR NIH HHS UL1 RR031990
6 · The paper itself

Abstract

objectivesTo determine the extent to which the use of a clinical informatics tool that implements prospective monitoring plans reduces the incidence of potential delirium, falls, hospitalizations potentially due to adverse drug events, and mortality.

designRandomized cluster trial.

settingTwenty-five nursing homes serviced by two long-term care pharmacies.

participantsResidents living in nursing homes during 2003 (1,711 in 12 intervention; 1,491 in 13 usual care) and 2004 (1,769 in 12 intervention; 1,552 in 13 usual care).

interventionThe pharmacy automatically generated Geriatric Risk Assessment MedGuide (GRAM) reports and automated monitoring plans for falls and delirium within 24 hours of admission or as part of the normal time frame of federally mandated drug regimen review. MEASUREMENTS: Incidence of potential delirium, falls, hospitalizations potentially due to adverse drug events, and mortality.

resultsGRAM triggered monitoring plans for 491 residents. Newly admitted residents in the intervention homes experienced a lower rate of potential delirium onset than those in usual care homes (adjusted hazard ratio (HR)=0.42, 95% confidence interval (CI)=0.35-0.52), overall hospitalization (adjusted HR=0.89, 95% CI=0.72-1.09), and mortality (adjusted HR=0.88, 95% CI=0.66-1.16). In longer stay residents, the effects of the intervention were attenuated, and all estimates included unity.

conclusionUsing health information technology in long-term care pharmacies to identify residents who might benefit from the implementation of prospective medication monitoring care plans when complex medication regimens carry potential risks for falls and delirium may reduce adverse effects associated with appropriate medication use.

Indexed as

PharmacistsAgedAged, 80 and overDeliriumDrug MonitoringDrug-Related Side Effects and Adverse ReactionsFemaleHumansMaleMonitoring, PhysiologicNursing HomesPharmacies

Identifiers

PMID21649623
PMCPMC3157676
OpenAlexW1540086567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.