ReviewJournal of pharmaceutical sciences2011
Multidimensional methods for the formulation of biopharmaceuticals and vaccines.
Review in Journal of pharmaceutical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations.Scientific reports · 2021Article
- Article
- DSPE-PEG Modification of α-Conotoxin TxID.Marine drugs · 2019Article
- Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want.NPJ vaccines · 2018Review
- Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach.International journal of nanomedicine · 2018Article
- Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant.Journal of pharmaceutical sciences · 2017Article
- Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Early implementation of QbD in biopharmaceutical development: a practical example.BioMed research international · 2015Review
- The effect of fiber truncations on the stability of adenovirus type 5.Molecular biotechnology · 2014Article
- High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability.The AAPS journal · 2014Review
- Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles.Frontiers in pharmacology · 2014Review
- Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques.Journal of pharmaceutical sciences · 2013Article
- Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis.Human vaccines & immunotherapeutics · 2013Article
- A systematic approach toward stabilization of CagL, a protein antigen from Helicobacter pylori that is a candidate subunit vaccine.Journal of pharmaceutical sciences · 2013Article
- Article
- Article
- Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome.Expert review of vaccines · 2012Article
- Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue.Journal of pharmaceutical sciences · 2012Article
- Improved data visualization techniques for analyzing macromolecule structural changes.Protein science : a publication of the Protein Society · 2012Article
- Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects.Expert review of vaccines · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Determining and preserving the higher order structural integrity and conformational stability of proteins, plasmid DNA, and macromolecular complexes such as viruses, virus-like particles, and adjuvanted antigens are often a significant barrier to the successful stabilization and formulation of biopharmaceutical drugs and vaccines. These properties typically must be investigated with multiple lower resolution experimental methods because each technique monitors only a narrow aspect of the overall conformational state of a macromolecular system. This review describes the use of empirical phase diagrams (EPDs) to combine large amounts of data from multiple high-throughput instruments and construct a map of a target macromolecule's physical state as a function of temperature, solvent conditions, and other stress variables. We present a tutorial on the mathematical methodology, an overview of some of the experimental methods typically used, and examples of some of the previous major formulation applications. We also explore novel applications of EPDs including potential new mathematical approaches as well as possible new biopharmaceutical applications such as analytical comparability, chemical stability, and protein dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.