Evidence map›Paper›PMID 21647843›Full record

ReviewEndocrine pathology2011

MicroRNAs in the human pituitary.

Milani Sivapragasam, Fabio Rotondo, Ricardo V Lloyd, Bernd W Scheithauer, Michael Cusimano, Luis V Syro, Kalman Kovacs

Abstract readReview
PubMed Publisher
In one paragraph

Review in Endocrine pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 52 citations in OpenAlex.

  1. Architects of Pituitary Tumour Growth.Frontiers in endocrinology · 2022
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Effect of miR-106b on Invasiveness of Pituitary Adenoma via PTEN-PI3K/AKT.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  11. Expression and Clinical Significance of miR-26a and Pleomorphic Adenoma Gene 1 (PLAG1) in Invasive Pituitary Adenoma.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
  12. Review
  13. Circulating miRNAs as biomarkers for endocrine disorders.Journal of endocrinological investigation · 2016
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Milani SivapragasamDepartment of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, ON M5B1W8, Canada.
Fabio Rotondo
Ricardo V Lloyd
Bernd W Scheithauer
Michael Cusimano
Luis V Syro
Kalman Kovacs
University of Toronto · CAHospital Pablo Tobon Uribe · COMayo Clinic · USSt. Michael's Hospital · CAUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) represent a novel class of small RNA molecules that play a crucial role as post-transcriptional regulators of gene expression. As evidence for the involvement of miRNAs in various cellular processes increases, it is important to examine how miRNAs regulate gene expression. In the pituitary, aberrant miRNA expression is strongly linked with neoplasia, thus suggesting they play a role in the control of cell proliferation in adenomas. Research has built fundamental connections between aberrant miRNA expression and clinicopathological features of pituitary adenomas. Moreover, deregulated expression of miRNA target genes is often implicated in important biological pathways and thus provides significant insight into the role of miRNAs in tumorigenesis. This review will assess the significance of miRNAs in pituitary pathology.

Indexed as

AdenomaAnimalsAntineoplastic AgentsGene Expression Regulation, NeoplasticHumansMicroRNAsPituitary GlandPituitary NeoplasmsSignal TransductionSpecies SpecificityAntineoplastic AgentsMicroRNAs

Identifiers

PMID21647843
OpenAlexW2014896525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.