ArticleSurgical endoscopy2011
Risk factors for recurrence after transanal endoscopic microsurgery for rectal malignant neoplasm.
Article in Surgical endoscopy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06043999 (A Prospective, Multicenter, Randomized, Open, Parallel Controlled, Non-inferiority Clinical Trial of Salvage Chemoradiotherapy Versus Radical Total Mesorectal Excision in the Treatment of Intermediate-risk Early Middle-low Rectal Cancer After Local Resection), which is not on this map. Cited by 44 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Multicenter, Randomized, Open, Parallel Controlled, Non-inferiority Clinical Trial of Salvage Chemoradiotherapy Versus Radical Total Mesorectal Excision in the Treatment of Intermediate-risk Early Middle-low Rectal Cancer After Local Resection
Who cites it
44 citing papers in PubMed, 8 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Efficacy and safety of transanal endoscopic microsurgery for early rectal cancer: a meta-analysis.Frontiers in oncology · 2025Pooled it
- Transanal endoscopic microsurgery versus radical resection for early-stage rectal cancer: a systematic review and meta- analysis.International journal of colorectal disease · 2023Pooled it
- Risk of recurrence after local resection of T1 rectal cancer: a meta-analysis with meta-regression.Surgical endoscopy · 2022Pooled it
- Local recurrence after local excision of early rectal cancer: a meta-analysis of completion TME, adjuvant (chemo)radiation, or no additional treatment.The British journal of surgery · 2020Pooled it
- Executive Summary of the American Radium Society Appropriate Use Criteria for Local Excision in Rectal Cancer.International journal of radiation oncology, biology, physics · 2019Guideline
- Practice parameters for early rectal cancer management: Italian Society of Colorectal Surgery (Società Italiana di Chirurgia Colo-Rettale; SICCR) guidelines.Techniques in coloproctology · 2015Guideline
- Early rectal cancer: the European Association for Endoscopic Surgery (EAES) clinical consensus conference.Surgical endoscopy · 2015Guideline
- Systematic review and meta-analysis of endoscopic submucosal dissection versus transanal endoscopic microsurgery for large noninvasive rectal lesions.Surgical endoscopy · 2014Pooled it
- A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer.BMC cancer · 2016Trial
- Peritoneal opening during transanal endoscopic microsurgery: can preoperative positioning assessment improve intraoperative management?Surgical endoscopy · 2026Article
- Geriatric Approaches to Rectal Cancer: Moving Towards a Patient-Tailored Treatment Era.Journal of clinical medicine · 2025Review
- Local Recurrence of Premalignant and Early Malignant Rectal Polyps Treated by TEM-A Single-Center Experience.Journal of clinical medicine · 2024Article
- Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center.World journal of gastrointestinal oncology · 2024Article
- Risk Factors for Rectal Cancer Recurrence after Local Excision of T1 Lesions from a Decade-Long Multicenter Retrospective Study.Journal of clinical medicine · 2024Article
- Article
- Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy.The Cochrane database of systematic reviews · 2023Review
- Transanal endoscopic microsurgery after the attempt of endoscopic removal of rectal polyps.Surgical endoscopy · 2022Article
- Local full-thickness excision for sessile adenoma and cT1-2 rectal cancer: long-term oncological outcome.Langenbeck's archives of surgery · 2022Article
- Transanal endoscopic microsurgery: exploring its indications and novel applications. A narrative review.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022Review
- Timing of recurrences of TEM resected rectal neoplasms is variable as per the surveillance practices of one tertiary care institution.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndications and results of local excision of rectal lesions are currently under debate. Transanal endoscopic microsurgery (TEM), allowing a precise, full-thickness excision, could improve oncological results in early rectal tumors.
methodsA prospective database was analyzed with the intent to identify risk factors for recurrence after TEM.
resultsAmong 355 patients subjected to TEM, 107 had an adenocarcinoma: 48 pT1, 43 pT2, and 16 pT3. Comparing pre- and postoperative data, histological discrepancy was 20% and staging discrepancy was 34%. Mortality was nil, morbidity was 9%. Mean follow-up was 54.2 months (range = 12-164), follow-up rate was 100%. The 5-year disease-free survival rate was 85.9, 78.4, and 49.4% for pT1, pT2, and pT3, respectively (p = 0.006). Recurrence rate was 0% (0/26) in pT1sm1 cancers and 22.7% (5/22) in sm2-3 (p < 0.05). A submucosal infiltration represented a significant risk factor for recurrences: 0% sm1, 16.7% sm2, and 30% sm3. Recurrence in pT2 was 0% in patients who had neoadjuvant therapy and 26% in the others. At univariate analysis, diameter, sm stage, pT stage, tumor grading, margin infiltration, and lymphovascular invasion demonstrated statistical significance. Multivariate analysis indicated sm stage, pT stage, and tumor grading as independent predictors of recurrence.
conclusionsTEM represents an effective curative treatment for pT1 sm1 rectal malignancies. pT1 sm2-3 patients should be considered high-risk cases if treated only by TEM. A consistent improvement in the preoperative assessment of the risk factors identified by the present study will be a crucial development for optimal treatment of early rectal cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.