Trial reportEuropean journal of nuclear medicine and molecular imaging2011
Predictive value of brain perfusion SPECT for rTMS response in pharmacoresistant depression.
Trial report in European journal of nuclear medicine and molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Biological markers in noninvasive brain stimulation trials in major depressive disorder: a systematic review.The journal of ECT · 2014Pooled it
- Abnormal Anterior Cingulate N-Acetylaspartate and Executive Functioning in Treatment-Resistant Depression After rTMS Therapy.The international journal of neuropsychopharmacology · 2015Trial
- Cerebral and cervical hemodynamic differences in adolescents with first-episode depressive disorder: a TCCD and cervical artery ultrasound study.Frontiers in psychiatry · 2026Article
- Neuroimaging Correlates of Treatment Response to Transcranial Magnetic Stimulation in Bipolar Depression: A Systematic Review.Brain sciences · 2023Review
- Predictors of remission after repetitive transcranial magnetic stimulation for the treatment of major depressive disorder: An analysis from the randomised non-inferiority THREE-D trial.EClinicalMedicine · 2020Article
- Baseline Difference in Quantitative Electroencephalography Variables Between Responders and Non-Responders to Low-Frequency Repetitive Transcranial Magnetic Stimulation in Depression.Frontiers in psychiatry · 2020Article
- White matter integrity and functional predictors of response to repetitive transcranial magnetic stimulation for posttraumatic stress disorder and major depression.Depression and anxiety · 2019Article
- Review
- Multimodal Molecular Imaging: Current Status and Future Directions.Contrast media & molecular imaging · 2018Review
- Microstructural Abnormalities of Basal Ganglia and Thalamus in Bipolar and Unipolar Disorders: A Diffusion Kurtosis and Perfusion Imaging Study.Psychiatry investigation · 2017Article
- Changes in dorsolateral prefrontal connectivity after rTMS in treatment-resistant depression: a brain perfusion SPECT study.European journal of nuclear medicine and molecular imaging · 2017Article
- Anaesthesia, not number of sessions, influences the magnitude and duration of an aHF-rTMS in dogs.PloS one · 2017Article
- Use of the Temperament and Character Inventory to Predict Response to Repetitive Transcranial Magnetic Stimulation for Major Depression.Journal of psychiatric practice · 2016Article
- Acute Stressors Reduce Neural Inhibition to Food Cues and Increase Eating Among Binge Eating Disorder Symptomatic Women.Frontiers in behavioral neuroscience · 2016Article
- Neural Network Based Response Prediction of rTMS in Major Depressive Disorder Using QEEG Cordance.Psychiatry investigation · 2015Article
- Differences in neural activation to depictions of physical exercise and sedentary activity: an fMRI study of overweight and lean Chinese women.International journal of obesity (2005) · 2014Article
- Ant Colony Optimization Based Feature Selection Method for QEEG Data Classification.Psychiatry investigation · 2014Article
- Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects.Progress in neuro-psychopharmacology & biological psychiatry · 2013Article
- Schizophrenia with preserved insight is associated with increased perfusion of the precuneus.Journal of psychiatry & neuroscience : JPN · 2012Article
- Improvement of health-related quality of life in depression after transcranial magnetic stimulation in a naturalistic trial is associated with decreased perfusion in precuneus.Health and quality of life outcomes · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to determine the predictive value of whole-brain voxel-based regional cerebral blood flow (rCBF) for repetitive transcranial magnetic stimulation (rTMS) response in patients with pharmacoresistant depression.
methodsThirty-three right-handed patients who met DSM-IV criteria for major depressive disorder (unipolar or bipolar depression) were included before rTMS. rTMS response was defined as at least 50% reduction in the baseline Beck Depression Inventory scores. The predictive value of (99m)Tc-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) for rTMS response was studied before treatment by comparing rTMS responders to non-responders at voxel level using Statistical Parametric Mapping (SPM) (p < 0.001, uncorrected).
resultsOf the patients, 18 (54.5%) were responders to rTMS and 15 were non-responders (45.5%). There were no statistically significant differences in demographic and clinical characteristics (p > 0.10). In comparison to responders, non-responders showed significant hypoperfusions (p < 0.001, uncorrected) in the left medial and bilateral superior frontal cortices (BA10), the left uncus/parahippocampal cortex (BA20/BA35) and the right thalamus. The area under the curve for the combination of SPECT clusters to predict rTMS response was 0.89 (p < 0.001). Sensitivity, specificity, positive predictive value and negative predictive value for the combination of clusters were: 94, 73, 81 and 92%, respectively.
conclusionThis study shows that, in pharmacoresistant depression, pretreatment rCBF of specific brain regions is a strong predictor for response to rTMS in patients with homogeneous demographic/clinical features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.