ArticleIntensive care medicine2011
Brain temperature in volunteers subjected to intranasal cooling.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04973085 (Effect of a Novel Cooling Device on Brain Temperature), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Novel Cooling Device on Brain Temperature
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Therapeutic Hypothermia for Neurological Injuries: Balancing Neuroprotection with Risks.Advances in experimental medicine and biology · 2026Review
- Multimodal Neuroprotection in Ischemic Stroke: Emerging Non-Pharmacological Interventions from Bench to Bedside.Brain sciences · 2025Review
- Therapeutic hypothermia for acute ischemic stroke: from preclinical studies to clinical trials.Science China. Life sciences · 2025Review
- Multi-Target and Multi-Phase Adjunctive Cerebral Protection for Acute Ischemic Stroke in the Reperfusion Era.Biomolecules · 2024Review
- Selective head cooling in the acute phase of concussive injury: a neuroimaging study.Frontiers in neurology · 2023Article
- Active conductive head cooling of normal and infarcted brain: A magnetic resonance spectroscopy imaging study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Selective Brain Cooling: A New Horizon of Neuroprotection.Frontiers in neurology · 2022Review
- Inducing therapeutic hypothermia via selective brain cooling: a finite element modeling analysis.Medical & biological engineering & computing · 2019Article
- Obesity, but not hypohydration, mediates changes in mental task load during passive heating in females.PeerJ · 2018Article
- Image-guided thermal ablation with MR-based thermometry.Quantitative imaging in medicine and surgery · 2017Review
- An injured brain needs cooling down: no.Intensive care medicine · 2015Article
- The effect of selective head-neck cooling on physiological and cognitive functions in healthy volunteers.Translational neuroscience · 2015Article
- A novel head-neck cooling device for concussion injury in contact sports.Translational neuroscience · 2015Article
- In cold blood: intraarteral cold infusions for selective brain cooling in stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
- Influence of intranasal and carotid cooling on cerebral temperature balance and oxygenation.Frontiers in physiology · 2014Article
- Intranasal administration of oxytocin: behavioral and clinical effects, a review.Neuroscience and biobehavioral reviews · 2013Article
- First clinical experience with intranasal cooling for hyperthermia in brain-injured patients.Neurocritical care · 2013Observational
- Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals.Intensive care medicine · 2012Article
- Therapeutic hypothermia for acute neurological injuries.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Research progress of selective brain cooling methods in the prehospital care for stroke patients: A narrative review.Brain circulationReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntranasal cooling can be used to initiate therapeutic hypothermia. However, direct measurement of brain temperature is difficult and the intra-cerebral distribution of temperature changes with cooling is unknown. The purpose of this study was to measure the brain temperature of human volunteers subjected to intranasal cooling using non-invasive magnetic resonance (MR) methods.
methodsIntranasal balloons catheters circulated with saline at 20°C were applied for 60 min in ten awake volunteers. No sedation was used. Brain temperature changes were measured and mapped using MR spectroscopic imaging (MRSI) and phase-mapping techniques. Heart rate and blood pressure were monitored throughout the experiment. Rectal temperature was measured before and after the cooling. Mini Mental State Examination (MMSE) test and nasal inspection were done before and after the cooling. Questionnaires about the subjects' personal experience were completed after the experiment.
resultsBrain temperature decrease measured by MRSI was -1.7 ± 0.8°C and by phase-mapping -1.8 ± 0.9°C (n = 9) at the end of cooling. Spatial distribution of temperature changes was relatively uniform. Rectal temperature decreased by -0.5 ± 0.3°C (n = 5). The physiological parameters were stable and no shivering was reported. The volunteers remained alert during cooling and no cognitive dysfunctions were apparent in the MMSE test. Postcooling nasal examination detected increased nasal secretion in nine of the ten volunteers. Volunteers' acceptance of the method was good.
conclusionBoth MR techniques revealed brain temperature reductions after 60 min of intranasal cooling with balloons circulated with saline at 20°C in awake, unsedated volunteers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.