ArticleJournal of molecular neuroscience : MN2012
Distribution of alarin immunoreactivity in the mouse brain.
Article in Journal of molecular neuroscience : MN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications.Frontiers in endocrinology · 2022Review
- Regulatory effects and potential therapeutic implications of alarin in depression, and arguments on its receptor.Frontiers in psychiatry · 2022Review
- Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord.Frontiers in endocrinology · 2022Review
- Neuropeptidergic Control of Feeding: Focus on the Galanin Family of Peptides.International journal of molecular sciences · 2021Review
- Alarin in different human intestinal epithelial cell types.Histochemistry and cell biology · 2019Article
- Galanin-like peptide (GALP) neurone-specific phosphoinositide 3-kinase signalling regulates GALP mRNA levels in the hypothalamus of males and luteinising hormone levels in both sexes.Journal of neuroendocrinology · 2014Article
- Expression of alarin in ependymoma and choroid plexus tumors.Journal of neuro-oncology · 2013Article
- Galanin receptors and ligands.Frontiers in endocrinology · 2012Article
- Beyond Leptin: Emerging Candidates for the Integration of Metabolic and Reproductive Function during Negative Energy Balance.Frontiers in endocrinology · 2011Article
- Thermoregulatory effect of alarin, a new member of the galanin peptide family.Temperature (Austin, Tex.)Article
- A paradoxical role for alarin in the nervous control of energy homeostasis and thermoregulation: orexigenic but hypermetabolic.Temperature (Austin, Tex.)Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alarin is a 25 amino acid peptide that belongs to the galanin peptide family. It is derived from the galanin-like peptide gene by a splice variant, which excludes exon 3. Alarin was first identified in gangliocytes of neuroblastic tumors and later shown to have a vasoactive function in the skin. Recently, alarin was demonstrated to stimulate food intake as well as the hypothalamic-pituitary-gonadal axis in rodents, suggesting that it might be a neuromodulatory peptide in the brain. However, the individual neurons in the central nervous system that express alarin have not been identified. Here, we determined the distribution of alarin-like immunoreactivity (alarin-LI) in the adult murine brain. The specificity of the antibody against alarin was demonstrated by the absence of labeling after pre-absorption of the antiserum with synthetic alarin peptide and in transgenic mouse brains lacking neurons expressing the GALP gene. Alarin-LI was observed in different areas of the murine brain. A high intensity of alarin-LI was detected in the accessory olfactory bulb, the medial preoptic area, the amygdala, different nuclei of the hypothalamus such as the arcuate nucleus and the ventromedial hypothalamic nucleus, the trigeminal complex, the locus coeruleus, the ventral chochlear nucleus, the facial nucleus, and the epithelial layer of the plexus choroideus. The distinct expression pattern of alarin in the adult mouse brain suggests potential functions in reproduction and metabolism.
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