ReviewDigestive diseases and sciences2011
Cryptogenic chronic hepatitis and its changing guise in adults.
Review in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Genetics of liver disease in adults.Hepatology communications · 2024Review
- Cryptogenic chronic hepatitis: looking for an ideal diagnostic algorithm.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Article
- Cryptogenic hepatitis patients have a higher Bartonella sp.-DNA detection in blood and skin samples than patients with non-viral hepatitis of known cause.PLoS neglected tropical diseases · 2022Article
- Undiagnosed liver diseases.Translational gastroenterology and hepatology · 2021Review
- Explant liver evaluation decodes the mystery of cryptogenic cirrhosis!JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Clinical utility of genomic analysis in adults with idiopathic liver disease.Journal of hepatology · 2019Article
- Searching for unknown transfusion-transmitted hepatitis viruses: a binational cohort study of 1.5 million transfused patients.Journal of internal medicine · 2018Article
- Unexplained chronic liver disease in Ethiopia: a cross-sectional study.BMC gastroenterology · 2018Article
- Global Disparities and Their Implications in the Occurrence and Outcome of Autoimmune Hepatitis.Digestive diseases and sciences · 2017Review
- The Enigma of Hepatitis E Virus.Gastroenterology & hepatology · 2017Article
- Adaptive immunity in the liver.Cellular & molecular immunology · 2016Review
- Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions.Gut and liver · 2016Review
- Transitioning from Idiopathic to Explainable Autoimmune Hepatitis.Digestive diseases and sciences · 2015Review
- Association Between TT Virus Infection and Cirrhosis in Liver Transplant Patients.Hepatitis monthly · 2015Article
- Acute and acute severe (fulminant) autoimmune hepatitis.Digestive diseases and sciences · 2013Review
- Occult hepatitis C virus infection in candidates for liver transplant with cryptogenic cirrhosis.Hepatitis monthly · 2013Article
- Celiac disease markers in patients with liver diseases: a single center large scale screening study.World journal of gastroenterology · 2012Article
- Diagnosis, pathogenesis, and treatment of autoimmune hepatitis after liver transplantation.Digestive diseases and sciences · 2012Review
- Keratin 8 variants are associated with cryptogenic hepatitis.Virchows Archiv : an international journal of pathology · 2012Article
- Cryptogenic hepatitis and bartonellosis.Digestive diseases and sciences · 2012Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptogenic chronic hepatitis is a disease that is unexplained by conventional clinical, laboratory and histological findings, and it can progress to cirrhosis, develop hepatocellular carcinoma, and require liver transplantation. The goals of this review are to describe the changing phenotype of cryptogenic chronic hepatitis in adults, develop a diagnostic algorithm appropriate to current practice, and suggest treatment options. The frequency of cryptogenic hepatitis is estimated at 5.4%. Cryptogenic cirrhosis is diagnosed in 5-30% of patients with cirrhosis, and it is present in 3-14% of adults awaiting liver transplantation. Nonalcoholic fatty liver disease has been implicated in 21-63% of patients, and autoimmune hepatitis is a likely diagnosis in 10-54% of individuals. Viral infections, hereditary liver diseases, celiac disease, and unsuspected alcohol or drug-induced liver injury are recognized infrequently in the current cryptogenic population. Manifestations of the metabolic syndrome heighten the suspicion of nonalcoholic fatty liver disease, and the absence of hepatic steatosis does not discount this possibility. The diagnostic scoring system of the International Autoimmune Hepatitis Group can support the diagnosis of autoimmune hepatitis in some patients. Certain genetic mutations may have disease-specificity, and they suggest that some patients may have an independent and uncharacterized disease. Corticosteroid therapy is effective in patients with autoimmune features, and life-style changes and specific therapies for manifestations of the metabolic syndrome are appropriate for all obese patients. The 1- and 5-year survivals after liver transplantation have ranged from 72-85% to 58-73%, respectively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.