ArticleCanadian journal of gastroenterology = Journal canadien de gastroenterologie2011
Interstitial cells of Cajal: a novel hypothesis for the pathophysiology of irritable bowel syndrome.
Article in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The Association Between Irritable Bowel Syndrome and Generalized Anxiety Disorder and Influencing Factors: A Mediation Mendelian Randomization Study.Food science & nutrition · 2026Article
- Exploring the gut microbiota's crucial role in acute pancreatitis and the novel therapeutic potential of derived extracellular vesicles.Frontiers in pharmacology · 2024Review
- Review
- Gut microbiome in acute pancreatitis: A review based on current literature.World journal of gastroenterology · 2021Review
- Dietary modulation of gut microbiota for the relief of irritable bowel syndrome.Nutrition research and practice · 2021Review
- Short chain fatty acids and colon motility in a mouse model of irritable bowel syndrome.BMC gastroenterology · 2021Article
- Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats.World journal of gastroenterology · 2019Article
- Neuronal Nitric Oxide Synthase Is a Novel Biomarker for the Interstitial Cells of Cajal in Stress-Induced Diarrhea-Dominant Irritable Bowel Syndrome.Digestive diseases and sciences · 2018Article
- Role of stem cell growth factor/c-Kit in the pathogenesis of irritable bowel syndrome.Experimental and therapeutic medicine · 2017Article
- Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart.Frontiers in physiology · 2016Review
- Mechanisms of Electrical Activation and Conduction in the Gastrointestinal System: Lessons from Cardiac Electrophysiology.Frontiers in physiology · 2016Review
- Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist?Oman medical journal · 2015Article
- The protective effects of total phenols in magnolia officinalix rehd. et wils on gastrointestinal tract dysmotility is mainly based on its influence on interstitial cells of cajal.International journal of clinical and experimental medicine · 2015Article
- Co-culture of neuroepithelial stem cells with interstitial cells of Cajal results in neuron differentiation.International journal of clinical and experimental medicine · 2015Article
- Acupuncture-moxibustion in treating irritable bowel syndrome: how does it work?World journal of gastroenterology · 2014Review
- Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome.Clinical and experimental gastroenterology · 2014Article
- Magnolol pretreatment prevents sepsis-induced intestinal dysmotility by maintaining functional interstitial cells of Cajal.Inflammation · 2013Article
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Authors and funding
2 authors.
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Abstract
Irritable bowl syndrome (IBS) affects a large proportion of the world's population, and accounts for a considerable number of visits to gastroenterologists and general practitioners. Despite its high prevalence, the precise mechanism of IBS has not been identified to date. The interstitial cells of Cajal (ICC) participate in the production of slow waves and the regulation of their propagation through the gastrointestinal system; thus, they are important components of gastrointestinal motility. The present review proposes that ICC play a central role in the pathophysiology of IBS. This hypothesis is based on many links between ICC and currently proposed mechanisms of IBS pathophysiology. It appears that ICC may be involved in almost all of the previously explained pathogenic mechanisms of IBS. If proven, this hypothesis may provide a key to solving the IBS mystery.
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