ArticleFrontiers in psychiatry2011
Epigenetics of early child development.
Article in Frontiers in psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Pooled it
- Perinatal stress and methylation of theEpigenetics · 2022Pooled it
- The Effectiveness and Cost-effectiveness of a Parenting Intervention Integrated with Primary Health Care on Early Childhood Development: a Cluster-Randomized Controlled Trial.Prevention science : the official journal of the Society for Prevention Research · 2020Trial
- …And Breathe! Wellness, the Nation, and Holistic Reproductive Practitioners in India.Culture, medicine and psychiatry · 2026Article
- Age- and sex-specific percentile curves for gross and fine motor skills in early childhood: an analysis from the SUNRISE International Study.European journal of pediatrics · 2026Article
- Physical Activity Before and During Pregnancy and Neurodevelopment in Early Childhood.JAMA network open · 2026Article
- Biological Effects of Music Therapy in End-of-Life Care: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Beyond a simple cause and effect relationship: Exploring the long-term outcomes of children prenatally exposed to opioids and other substances.Seminars in perinatology · 2025Review
- Birth weight discordance, gene expression, and DNA methylation: A scoping review of epigenetic twin studies.PloS one · 2025Article
- Anthropometric indices growth references (length, Weight and Head Circumferences) of children aged 0-24 months in North-East of Iran by GAMLSS.BMC pediatrics · 2024Article
- Review
- The embodiment of parental death in early life through accelerated epigenetic aging: Implications for understanding how parental death before 18 shapes age-related health risk among older adults.SSM - population health · 2024Article
- Parental stress and child stimulation practices: examining associations with child developmental outcomes over time in Kenya and Zambia.BMC psychology · 2024Article
- Combined effects of physical activity and life events on depression and PTSD in Chinese students aged 16-24 years.Frontiers in public health · 2024Article
- Mental health and well-being in children and adolescents.Indian journal of psychiatry · 2024Article
- Perinatal Factors and Emotional, Cognitive, and Behavioral Dysregulation in Childhood and Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- An epigenetic mechanism for over-consolidation of fear memories.Molecular psychiatry · 2022Article
- A Non-Randomized Pilot Study on the Benefits of Baby Swimming on Motor Development.International journal of environmental research and public health · 2022Article
- Social skills and psychopathology are associated with autonomic function in children: a cross-sectional observational study.Neural regeneration research · 2022Article
- Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression.International journal of molecular sciences · 2021Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comprehensive clinical studies show that adverse conditions in early life can severely impact the developing brain and increase vulnerability to mood disorders later in life. During early postnatal life the brain exhibits high plasticity which allows environmental signals to alter the trajectories of rapidly developing circuits. Adversity in early life is able to shape the experience-dependent maturation of stress-regulating pathways underlying emotional functions and endocrine responses to stress, such as the hypothalamo-pituitary-adrenal (HPA) system, leading to long-lasting altered stress responsivity during adulthood. To date, the study of gene-environment interactions in the human population has been dominated by epidemiology. However, recent research in the neuroscience field is now advancing clinical studies by addressing specifically the mechanisms by which gene-environment interactions can predispose individuals toward psychopathology. To this end, appropriate animal models are being developed in which early environmental factors can be manipulated in a controlled manner. Here we will review recent studies performed with the common aim of understanding the effects of the early environment in shaping brain development and discuss the newly developing role of epigenetic mechanisms in translating early life conditions into long-lasting changes in gene expression underpinning brain functions. Particularly, we argue that epigenetic mechanisms can mediate the gene-environment dialog in early life and give rise to persistent epigenetic programming of adult physiology and dysfunction eventually resulting in disease. Understanding how early life experiences can give rise to lasting epigenetic marks conferring increased risk for mental disorders, how they are maintained and how they could be reversed, is increasingly becoming a focus of modern psychiatry and should pave new guidelines for timely therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.