Evidence map›Paper›PMID 21647396›Full record

ArticleFrontiers in aging neuroscience2011

Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress.

Ashok Kumar

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

  1. The endocannabinoid system and the ageing brain.Nature reviews. Neuroscience · 2026
    Review
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  14. Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  15. Contributions of site- and sex-specific LTPs to everyday memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  16. Article
  17. Article
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  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Ashok KumarDepartment of Neuroscience, McKnight Brain Institute, University of Florida Gainesville, FL, USA.

Funding

Estrogen and cognition over the lifespanR01AG037984 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C, KUMAR, ASHOK · 2011 to 2022
$3.3M
Signaling cascades and memory deficits during agingR37AG036800 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C · 2010 to 2018
$2.6M
MECHANISMS FOR ALTERED SYNAPTIC FUNCTION DURING AGINGR01AG014979 · NIA · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI FOSTER, THOMAS C · 1998 to 2011
$2.5M
Estrogen and cognition over the lifespanR56AG037984 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C · 2010 to 2010
$271k
NIA NIH HHS R01 AG014979NIA NIH HHS R01 AG037984NIA NIH HHS R37 AG036800NIA NIH HHS R56 AG037984
6 · The paper itself

Abstract

Synaptic plasticity in the mammalian central nervous system has been the subject of intense investigation for the past four decades. Long-term potentiation (LTP), a major reflection of synaptic plasticity, is an activity-driven long-lasting increase in the efficacy of excitatory synaptic transmission following the delivery of a brief, high-frequency train of electrical stimulation. LTP is regarded as a principal candidate for the cellular mechanisms involved in learning and offers an attractive hypothesis of how memories are constructed. There are a number of exceptional full-length reviews published on LTP; the current review intends to present an overview of the research findings regarding hippocampal LTP with special emphasis on aging, diseases, and psychological insults.

Indexed as

agingAlzheimer's diseasebrainhippocampusLTPstress

Identifiers

PMID21647396
PMCPMC3102214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.