ArticleFrontiers in behavioral neuroscience2011
Regulation of the Fear Network by Mediators of Stress: Norepinephrine Alters the Balance between Cortical and Subcortical Afferent Excitation of the Lateral Amygdala.
Article in Frontiers in behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Common brain activations for painful and non-painful aversive stimuli.BMC neuroscience · 2012Pooled it
- GABAA receptors predict aversion-related brain responses: an fMRI-PET investigation in healthy humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- A nuclei-specific fronto-amygdala pathway and its neurotransmitter receptor distribution: Implications for Antidepressant Selection.Molecular psychiatry · 2026Article
- Emotional Memory Processing during REM Sleep with Implications for Post-Traumatic Stress Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area.Molecular psychiatry · 2022Article
- Fear Network Model in Panic Disorder: The Past and the Future.Psychiatry investigation · 2019Article
- Noradrenergic Modulation of Fear Conditioning and Extinction.Frontiers in behavioral neuroscience · 2018Review
- Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis.Frontiers in molecular neuroscience · 2018Article
- Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice.Translational psychiatry · 2017Article
- Localization of the delta opioid receptor and corticotropin-releasing factor in the amygdalar complex: role in anxiety.Brain structure & function · 2017Article
- The neurobiology of social play and its rewarding value in rats.Neuroscience and biobehavioral reviews · 2016Review
- Mechanisms underlying the formation of the amygdalar fear memory trace: A computational perspective.Neuroscience · 2016Article
- Synaptic competition in the lateral amygdala and the stimulus specificity of conditioned fear: a biophysical modeling study.Brain structure & function · 2016Article
- Escitalopram reversed the traumatic stress-induced depressed and anxiety-like symptoms but not the deficits of fear memory.Psychopharmacology · 2016Article
- Biologically based neural circuit modelling for the study of fear learning and extinction.NPJ science of learning · 2016Article
- Article
- Safety Needs Mediate Stressful Events Induced Mental Disorders.Neural plasticity · 2016Review
- Neuronal correlates of depression.Cellular and molecular life sciences : CMLS · 2015Review
- Dopaminergic Modulation of Lateral Amygdala Neuronal Activity: Differential D1 and D2 Receptor Effects on Thalamic and Cortical Afferent Inputs.The international journal of neuropsychopharmacology · 2015Article
- Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Pavlovian auditory fear conditioning involves the integration of information about an acoustic conditioned stimulus (CS) and an aversive unconditioned stimulus in the lateral nucleus of the amygdala (LA). The auditory CS reaches the LA subcortically via a direct connection from the auditory thalamus and also from the auditory association cortex itself. How neural modulators, especially those activated during stress, such as norepinephrine (NE), regulate synaptic transmission and plasticity in this network is poorly understood. Here we show that NE inhibits synaptic transmission in both the subcortical and cortical input pathway but that sensory processing is biased toward the subcortical pathway. In addition binding of NE to β-adrenergic receptors further dissociates sensory processing in the LA. These findings suggest a network mechanism that shifts sensory balance toward the faster but more primitive subcortical input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.