ArticleInternational journal of biological sciences2011
Modeling the effects of a simple immune system and immunodeficiency on the dynamics of conjointly growing tumor and normal cells.
Article in International journal of biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Dynamics of Breast Cancer under Different Rates of Chemoradiotherapy.Computational and mathematical methods in medicine · 2019Article
- Modeling multi-mutation and drug resistance: analysis of some case studies.Theoretical biology & medical modelling · 2017Article
- Modeling drug resistance in a conjoint normal-tumor setting.Theoretical biology & medical modelling · 2015Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotherapeutic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations.
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