ArticleNucleus (Austin, Tex.)
An epichromatin epitope: persistence in the cell cycle and conservation in evolution.
Article in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Envelope-Limited Chromatin Sheets (ELCS) Formation in The Nuclear Envelope of HL-60/S4 Cells.bioRxiv : the preprint server for biology · 2026Article
- Regulation of chromatin architecture by protein binding: insights from molecular modeling.Biophysical reviews · 2024Review
- Interphase epichromatin: last refuge for the 30-nm chromatin fiber?Chromosoma · 2021Review
- Structures of Native-like Nucleosomes: One Step Closer toward Understanding the Structure and Function of Chromatin.Journal of molecular biology · 2021Review
- Hyperosmotic stress:Nucleus (Austin, Tex.) · 2020Article
- Linker histone epitopes are hidden by in situ higher-order chromatin structure.Epigenetics & chromatin · 2020Article
- Mesoscale Modeling of Nucleosome-Binding Antibody PL2-6: Mono- versus Bivalent Chromatin Complexes.Biophysical journal · 2020Article
- Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment.Nature communications · 2019Article
- Three-Dimensional Cellular Raman Analysis: Evidence of Highly Ordered Lipids Within Cell Nuclei.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Epichromatin and chromomeres: a 'fuzzy' perspective.Open biology · 2018Review
- Jörg Langowski: his scientific legacy and the future it promises.BMC biophysics · 2018Article
- Differential staining of peripheral nuclear chromatin with Acridine orange implies an A-form epichromatin conformation of the DNA.Nucleus (Austin, Tex.) · 2018Article
- Defining the epichromatin epitope.Nucleus (Austin, Tex.) · 2017Article
- Nucleosome repositioning during differentiation of a human myeloid leukemia cell line.Nucleus (Austin, Tex.) · 2017Article
- Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells.Nucleus (Austin, Tex.) · 2017Article
- Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide.Cell cycle (Georgetown, Tex.) · 2015Article
- ELCS in ice: cryo-electron microscopy of nuclear envelope-limited chromatin sheets.Chromosoma · 2014Article
- Epichromatin is conserved in Toxoplasma gondii and labels the exterior parasite chromatin throughout the cell cycle.Parasitology · 2013Article
- Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation.Chromosoma · 2012Review
- Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes.Nucleus (Austin, Tex.) · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interphase nuclear architecture is disrupted and rapidly reformed with each cell division cycle. Successive cell generations exhibit a "memory" of this nuclear architecture, as well as for gene expression. Furthermore, many features of nuclear and mitotic chromosome structure are recognizably species and tissue specific. We wish to know what properties of the underlying chromatin structure may determine these conserved features of nuclear architecture. Employing a particular mouse autoimmune anti-nucleosome monoclonal antibody (PL2-6), combined with deconvolution immunofluorescence microscopy, we present evidence for a unique epitope (involving a ternary complex of histones H2A and H2B and DNA) which is localized only at the exterior chromatin surface of interphase nuclei and mitotic chromosomes in mammalian, invertebrate and plant systems. As only the surface chromatin region is identified with antibody PL2-6, we have assigned it the name "epichromatin". We describe an "epichromatin hypothesis", suggesting that epichromatin may have a unique evolutionary conserved conformation which facilitates interaction with the reforming post-mitotic nuclear envelope and a rapid return of interphase nuclear architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.