ArticleNucleus (Austin, Tex.)
'Natively unfolded' nucleoporins in nucleocytoplasmic transport: clustered or evenly distributed?
Article in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Translocation of HIV capsid core through the Nuclear Pore Complex by affinity gradient.bioRxiv : the preprint server for biology · 2025Article
- Nuclear transport proteins: structure, function, and disease relevance.Signal transduction and targeted therapy · 2023Review
- Application of Super-resolution SPEED Microscopy in the Study of Cellular Dynamics.Chemical & biomedical imaging · 2023Review
- On the nuclear pore complex and its emerging role in cellular mechanotransduction.APL bioengineering · 2022Review
- Speed Microscopy: High-Speed Single Molecule Tracking and Mapping of Nucleocytoplasmic Transport.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Nuclear Transport Deficits in Tau-Related Neurodegenerative Diseases.Frontiers in neurology · 2020Review
- NUP214 in Leukemia: It's More than Transport.Cells · 2019Review
- Mechanosensing at the Nuclear Envelope by Nuclear Pore Complex Stretch Activation and Its Effect in Physiology and Pathology.Frontiers in physiology · 2019Article
- The selective permeability barrier in the nuclear pore complex.Nucleus (Austin, Tex.) · 2016Review
- High-resolution imaging reveals new features of nuclear export of mRNA through the nuclear pore complexes.International journal of molecular sciences · 2014Review
- Nuclear pore complex protein sequences determine overall copolymer brush structure and function.Biophysical journal · 2014Article
- Assembly of Nsp1 nucleoporins provides insight into nuclear pore complex gating.PLoS computational biology · 2014Article
- Enriching the pore: splendid complexity from humble origins.Traffic (Copenhagen, Denmark) · 2014Review
- Role of molecular charge in nucleocytoplasmic transport.PloS one · 2014Article
- In vivo analysis of human nucleoporin repeat domain interactions.Molecular biology of the cell · 2013Article
- High-resolution three-dimensional mapping of mRNA export through the nuclear pore.Nature communications · 2013Article
- Nuclear transport receptor binding avidity triggers a self-healing collapse transition in FG-nucleoporin molecular brushes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Distinct, but not completely separate spatial transport routes in the nuclear pore complex.Nucleus (Austin, Tex.)Review
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
The nuclear pore complex (NPC) acts as a selective gate that mediates the bidirectional transport of macromolecules between the cytoplasm and the nucleus of eukaryotic cells. 'Natively unfolded' nucleoporins (Nups) with domains rich in phenylalanine-glycine (FG) repeats form the selective permeability barrier and provide binding sites for mobile transport receptors in the NPC. Understanding the structure and function of the FG-Nups barrier under real-time trafficking conditions is still a formidable challenge due to the dynamic nature of a channeled membranous environment. Recently, we have shown that three-dimensional (3D) density maps of transient interactions between the FG-Nups barrier and a cargo-free or a cargo-bound transport receptor in native NPCs can be obtained by an advanced single-molecule fluorescence microscopy approach. Moreover, we found that these interaction sites are spatially clustered into distinct groups in the periphery around a central axial channel with a diameter of approximately 10-20 nm in the NPC. The 3D distribution of interaction sites may indicate some native properties of the FG-Nups barrier. Here we speculate that the selective permeability barrier in the NPC could be formed by clustered FG-Nups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.