SynthesisProstate cancer and prostatic diseases2011
XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis.
Synthesis in Prostate cancer and prostatic diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 11 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Meta-Analysis of the Relationship between XRCC1-Arg399Gln and Arg280His Polymorphisms and the Risk of Prostate Cancer.Scientific reports · 2015Pooled it
- No association between XRCC1 genetic polymorphisms and differentiated thyroid carcinoma risk: a meta-analysis.Molecular biology reports · 2014Pooled it
- XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms in esophageal cancer risk: a meta-analysis.Digestive diseases and sciences · 2013Pooled it
- Quantitative assessment of the associations between XRCC1 polymorphisms and bladder cancer risk.World journal of surgical oncology · 2013Pooled it
- Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- GSTP1 Ile105Val polymorphism and prostate cancer risk: evidence from a meta-analysis.PloS one · 2013Pooled it
- Association between the XRCC1 polymorphisms and glioma risk: a meta-analysis of case-control studies.PloS one · 2013Pooled it
- Association between the XRCC1 Arg399Gln polymorphism and risk of cancer: evidence from 297 case-control studies.PloS one · 2013Pooled it
- Association between XRCC1 polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis.BMC medical genetics · 2012Pooled it
- X-ray repair cross-complementing group 1 polymorphisms and hepatocellular carcinoma: a meta-analysis.World journal of gastroenterology · 2012Pooled it
- Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies.PloS one · 2012Pooled it
- Article
- Liver Cirrhosis in Chronic Hepatitis B Patients Is Associated with Genetic Variations in DNA Repair Pathway Genes.Cancers · 2020Article
- Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer.The Prostate · 2016Article
- Confirmation of genetic variants associated with lethal prostate cancer in a cohort of men from hereditary prostate cancer families.International journal of cancer · 2015Article
- The association of XRCC3 Thr241Met genetic variant with risk of prostate cancer: a meta-analysis.African health sciences · 2015Article
- Base excision repair and cancer.Cancer letters · 2012Review
- East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians.Chinese journal of cancer · 2012Review
- The effect of ethnicity and sexual preference on prostate-cancer-related quality of life.Nature reviews. Urology · 2012Review
- Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population.Experimental and therapeutic medicine · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have evaluated the association between X-ray repair cross-complementing group 1 gene (XRCC1) Arg399Gln and Arg194Trp polymorphisms and risk of prostate cancer (PCa). However, the results from the published studies on the association between these two XRCC1 polymorphisms and PCa risk are conflicting. To derive a more precise estimation of association between the XRCC1 polymorphisms and risk of PCa, we performed a meta-analysis. A comprehensive search was conducted to identify all case-control studies of XRCC1 polymorphisms and PCa risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, we found that both Arg399Gln and Arg194Trp polymorphisms were not significantly associated with PCa risk. However, in stratified analysis by ethnicity, we found that the Arg399Gln polymorphism was significantly associated with PCa risk in Asian population (Gln/Gln vs Arg/Arg: OR=1.46, 95% CI: 1.05-2.03, P=0.03; Gln/Gln vs Arg/Gln+Arg/Arg: OR=1.48, 95% CI: 1.12-1.95, P=0.01). In this meta-analysis, we found that both Arg399Gln and Arg194Trp polymorphisms were not related to overall PCa risk. However, in subgroup analysis we found a suggestion that XRCC1 399Gln allele might be a low-penetrent risk factor for PCa only in Asian men.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.