ArticleThe pharmacogenomics journal2012
Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region.
Article in The pharmacogenomics journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Research progress on pharmacological effects and bioavailability of berberine.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Article
- Research progress on antidepressant effects and mechanisms of berberine.Frontiers in pharmacology · 2024Review
- Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Uncovering the Potential Mechanisms ofDrug design, development and therapy · 2022Article
- Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patientsWorld journal of gastroenterology · 2020Article
- Co-aminobenzamid@Al-SBA-15: a favorable catalyst in synthesis of 2,3-dihydroquinazolin-4(1BMC chemistry · 2019Article
- A promising antitumor activity of evodiamine incorporated in hydroxypropyl-β-cyclodextrin: pro-apoptotic activity in human hepatoma HepG2 cells.Chemistry Central journal · 2016Article
- Atrial Fibrillation Due to Over The Counter Stimulant Drugs in A Young Adult.Journal of clinical and diagnostic research : JCDR · 2015Article
- Pharmacogenomics and herb-drug interactions: merge of future and tradition.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Article
- Pharmacological actions of multi-target-directed evodiamine.Molecules (Basel, Switzerland) · 2013Review
- Modulation of human serotonin transporter expression by 5-HTTLPR in colon cells.International journal of molecular sciences · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effect of berberine and evodiamine on serotonin transporter (5-HTT) expression and then test how allelic variations previously identified in the promoter region could modulate that effect in the serotonergic neuronal cell line RN46A. Both berberine and evodiamine, alone and in combination, increased 5-HTT mRNA and protein expression significantly across the various alleles. When tested against the S, XS(11), L(G), L(A), XL(17), and XL(18) alleles, respectively, 100 μM berberine increased 5-HTT promoter activities by 67%, 128.7%, 106.9%, 100.4%, 26.2% and 82%, 2 μM evodiamine increased 5-HTT promoter activities by 216.7%, 81.6%, 305.6%, 181.5%, 175.3% and 102.2%. Berberine and evodiamine increased 5-HTT promoter activity differently depending on the genetic variation of the 5-HTTLPR polymorphism. This study has provided a convincing example of how herbal compounds influence the expression of one of the most intensively studied psychiatric candidate genes, the serotonin transporter.
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