ArticleImmunology and cell biology2012
SAP suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice.
Article in Immunology and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- Inhibitors of the Sialidase NEU3 as Potential Therapeutics for Fibrosis.International journal of molecular sciences · 2022Review
- Altered meningeal immunity contributing to the autism-like behavior of BTBRBrain, behavior, & immunity - health · 2022Article
- Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses.Frontiers in immunology · 2019Review
- Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with etomoxir or interferon-β.Scientific reports · 2018Article
- The Development of Serum Amyloid P as a Possible Therapeutic.Frontiers in immunology · 2018Review
- An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis.PloS one · 2018Article
- Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging.Frontiers in neurology · 2016Review
- No quiet surrender: molecular guardians in multiple sclerosis brain.The Journal of clinical investigation · 2015Review
- Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Mechanisms of action of therapeutic amyloidogenic hexapeptides in amelioration of inflammatory brain disease.The Journal of experimental medicine · 2014Article
- Janus faces of amyloid proteins in neuroinflammation.Journal of clinical immunology · 2014Review
- Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.PloS one · 2014Article
- New approaches to modulating idiopathic pulmonary fibrosis.Current allergy and asthma reports · 2013Review
- Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.Science translational medicine · 2013Article
- Host responses in tissue repair and fibrosis.Annual review of pathology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell-mediated disease of the central nervous system. Serum amyloid P component (SAP) is a highly conserved plasma protein named for its universal presence in amyloid deposits. Here we report that SAP-transgenic mice had unexpectedly attenuated EAE due to impaired encephalitogenic responses. Following induction with myelin oligodendroglial glycoprotein (MOG) peptide 35-55 in complete Freund's adjuvant, SAP-transgenic mice showed reduced spinal cord inflammation with lower severity of EAE attacks as compared with control C57BL/6 mice. However, in SAP-Knockout mice, the severity of EAE is enhanced. Adoptive transfer of Ag-restimulated T cells from wild type to SAP-transgenic mice, or transfer of SAP-transgenic Ag-restimulated T cells to control mice, induced milder EAE. T cells from MOG-primed SAP-transgenic mice showed weak proliferative responses. Furthermore, in SAP-transgenic mice, there is little infiltration of CD45-positive cells in the spinal cord. In vitro, SAP suppressed the secretion of interleukin-2 stimulated by P-selectin and blocked P-selectin binding to T cells. Moreover, SAP could change the affinity between α4-integrin and T cells. These data suggested that SAP could antagonize the development of the acute phase of inflammation accompanying EAE by modulating the function of P-selectin.
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Registered trials
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