Evidence map›Paper›PMID 21646577›Full record

ReviewArchives of general psychiatry2011

Translational epidemiology in psychiatry: linking population to clinical and basic sciences.

Myrna M Weissman, Alan S Brown, Ardesheer Talati

Abstract readReview
In one paragraph

Review in Archives of general psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Using the high-risk family design to identify biomarkers for major depression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013
    Article
  17. Article
  18. Article
  19. Early interventions for PTSD: a review.Depression and anxiety · 2012
    Review
  20. Translating epidemiology in psychiatry: the future is here.Epidemiology and psychiatric sciences · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Myrna M WeissmanDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA. mmw3@columbia.edu
Alan S Brown
Ardesheer Talati

Funding

Three Generations at High and Low Risk for Depression Followed LongitudinallyR01MH036197 · NIMH · YALE UNIVERSITY · PI POSNER, JONATHAN E, WEISSMAN, MYRNA M · 1985 to 2020
$15.0M
Serotonergic Modulation of Brain Development: Genetic and Pharmacologic InfluencP50MH090966 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GINGRICH, JAY A · 2010 to 2014
$9.6M
Prenatal Factors and Risk of Schizophrenia in a Finnish National Birth CohortR01MH082052 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BROWN, ALAN STEWART · 2008 to 2012
$4.3M
Epidemiology of Prenatal Factors and Adult PsychopathologyK02MH065422 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BROWN, ALAN STEWART · 2003 to 2012
$1.2M
Prenatal Smoke Exposure and Offspring Substance Use: An Imaging-Genetics ApproachK01DA029598 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI TALATI, ARDESHEER · 2010 to 2014
$906k
NIDA NIH HHS K01 DA029598NIMH NIH HHS 1P50MH090966NIMH NIH HHS K02 MH065422NIMH NIH HHS K02 MH065422-06NIMH NIH HHS P50 MH090966NIMH NIH HHS R01 MH036197NIMH NIH HHS R01 MH082052NIMH NIH HHS R01 MH082052-01NIMH NIH HHS R01 MH36197
6 · The paper itself

Abstract

Translational research generally refers to the application of knowledge generated by advances in basic sciences research translated into new approaches for diagnosis, prevention, and treatment of disease. This direction is called bench-to-bedside. Psychiatry has similarly emphasized the basic sciences as the starting point of translational research. This article introduces the term translational epidemiology for psychiatry research as a bidirectional concept in which the knowledge generated from the bedside or the population can also be translated to the benches of laboratory science. Epidemiologic studies are primarily observational but can generate representative samples, novel designs, and hypotheses that can be translated into more tractable experimental approaches in the clinical and basic sciences. This bedside-to-bench concept has not been explicated in psychiatry, although there are an increasing number of examples in the research literature. This article describes selected epidemiologic designs, providing examples and opportunities for translational research from community surveys and prospective, birth cohort, and family-based designs. Rapid developments in informatics, emphases on large sample collection for genetic and biomarker studies, and interest in personalized medicine--which requires information on relative and absolute risk factors--make this topic timely. The approach described has implications for providing fresh metaphors to communicate complex issues in interdisciplinary collaborations and for training in epidemiology and other sciences in psychiatry.

Indexed as

Epidemiologic MethodsData CollectionEpidemiologyHumansMental DisordersPsychiatryTranslational Research, Biomedical

Identifiers

PMID21646577
PMCPMC3268346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.