ArticleInfection and immunity2011
Activation of the contact system at the surface of Fusobacterium necrophorum represents a possible virulence mechanism in Lemièrre's syndrome.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Rare bacterial infections and metagenomics: current diagnostic and therapeutic challenges-a literature review.Infection · 2026Review
- Bacterial infection and activation of the contact pathway of coagulation.Blood vessels, thrombosis & hemostasis · 2025Review
- Microbiological diversity among patients with Lemierre syndrome and clinical implications: an individual patient-level analysis.Infection · 2025Article
- Proteomic Characterization of Plasma in Lemierre's Syndrome.Thrombosis and haemostasis · 2024Article
- A rare case of MRSA associated Lemierre's syndrome.IDCases · 2024Article
- Otogenic Cerebral Sinus Thrombosis in Children: A Narrative Review.Neurology and therapy · 2023Review
- Complex Lemierre syndrome with multisystemic abscesses.BMJ case reports · 2023Article
- Paediatric otogenic sinus venous thrombosis: the role ofActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Article
- Jugular Vein Thrombosis and Anticoagulation Therapy in Lemierre's SyndromeOpen forum infectious diseases · 2021Article
- Cell Receptor and Cofactor Interactions of the Contact Activation System and Factor XI.Frontiers in medicine · 2018Review
- Fusobacterium necrophorum otitis and mastoiditis in infants and young toddlers.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Review
- Invasive Fusobacterium necrophorum infections and Lemièrre's syndrome: the role of thrombophilia and EBV.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- The role of coagulation/fibrinolysis during Streptococcus pyogenes infection.Frontiers in cellular and infection microbiology · 2014Review
- Associations and outcomes of septic pulmonary embolism.The open respiratory medicine journal · 2014Article
- Streptococcal surface proteins activate the contact system and control its antibacterial activity.The Journal of biological chemistry · 2012Article
- The association of septic thrombophlebitis with septic pulmonary embolism in adults.The open respiratory medicine journal · 2012Article
- Antiphospholipid Syndrome-Associated Lemierre's Syndrome With Extensive Cervicothoracic Venous Thrombosis Mimicking Thoracic Outlet Syndrome.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusobacterium necrophorum causes Lemièrre's syndrome, a serious disease with septic thrombophlebitis of the internal jugular vein, pulmonary involvement, and systemic inflammation. The contact system is a link between inflammation and coagulation, and contact activation by the bacteria could therefore contribute to the abnormal coagulation and inflammation seen in patients with Lemièrre's syndrome. In this study, F. necrophorum was found to bind radiolabeled high-molecular-weight kininogen (HK), a central component of the contact system. Binding was inhibited by the addition of unlabeled HK and domain D5 of HK but not other components of the contact system, indicating a specific interaction mediated through the D5 region. Binding of HK was significantly reduced after pretreatment of the bacteria with trypsin, suggesting that surface proteins are involved in HK binding. Incubation of the bacteria with human plasma resulted in an HK breakdown pattern suggestive of bradykinin release, and bradykinin was also detected in the supernatant. In addition, we show that factor XI (FXI), another component of the contact system, binds to F. necrophorum and that the bound FXI reconstitutes the activated partial thromboplastin time of FXI-deficient plasma. Thrombin activity was detected at the surface of the bacteria following incubation with plasma, indicating that the intrinsic pathway of coagulation is activated at the surface. This activity was completely blocked by inhibitors of the contact system. The combined results show that the contact system is activated at the surface of F. necrophorum, suggesting a pathogenic role for this system in Lemièrre's syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.