ArticleMolecular and cellular biology1990
Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 64 citations in OpenAlex.
- The HPV E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network.The open virology journal · 2012Article
- Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability.The Journal of biological chemistry · 2009Article
- Characterization of the functional activities of the bovine papillomavirus type 1 E2 protein single-chain heterodimers.Journal of virology · 2006Article
- Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein.Oncogene · 2003Article
- Ski interacts with the evolutionarily conserved SNW domain of Skip.Nucleic acids research · 2001Article
- Stability of the human papillomavirus type 18 E2 protein is regulated by a proteasome degradation pathway through its amino-terminal transactivation domain.Journal of virology · 2001Article
- An enhanceosome containing the Jun B/Fra-2 heterodimer and the HMG-I(Y) architectural protein controls HPV 18 transcription.EMBO reports · 2000Article
- Adeno-associated virus type 2 rep protein inhibits human papillomavirus type 16 E2 recruitment of the transcriptional coactivator p300.Journal of virology · 2000Article
- Characterization of a novel quiescence responsive element downregulated by v-Src in the promoter of the neuroretina specific QR1 gene.Oncogene · 2000Article
- Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition.Journal of virology · 2000Article
- Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells.Journal of virology · 2000Article
- Article
- Human SWI-SNF component BRG1 represses transcription of the c-fos gene.Molecular and cellular biology · 1999Article
- Transient viral DNA replication and repression of viral transcription are supported by the C-terminal domain of the bovine papillomavirus type 1 E1 protein.Journal of virology · 1998Article
- Transcription activities of human papillomavirus type 11 E6 promoter-proximal elements in raft and submerged cultures of foreskin keratinocytes.Journal of virology · 1997Article
- Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins.Journal of virology · 1997Article
- Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins.Journal of virology · 1997Article
- Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein.Journal of virology · 1997Article
- Transcriptional and replicational activation functions in the bovine papillomavirus type 1 E2 protein are encoded by different structural determinants.Journal of virology · 1996Article
- Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions.Journal of virology · 1996Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The viral transcriptional factors encoded by the E2 open reading frame bind to the specific DNA sequence elements ACCGNNNNCGGT, allowing activation or repression of transcription. We have analyzed bovine papillomavirus type 1 E2 transactivation using recombinant genes containing E2-binding sites inserted at either 3' or 5' positions relative to the heterologous transcriptional initiation site of the herpes simplex virus thymidine kinase gene. In these hybrid plasmids, strong transactivation required the presence of a minimum of two E2-binding sites in close proximity to the promoter or five binding sites at a distance. The presence of a single E2-binding motif 5', close to the initiation site, increased the efficiency of E2 transactivation from a distance in a more-than-additive manner. Since each E2-binding site bound a dimer of the E2 protein, these experiments suggest that transactivation by E2 requires the interaction between several E2 dimers with other essential transcription factors. This interaction may be facilitated by DNA looping, which would bring E2 molecules close to the promoter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.