ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
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- Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction.American journal of physiology. Renal physiology · 2021Article
- Mast Cell Biology at Molecular Level: a Comprehensive Review.Clinical reviews in allergy & immunology · 2020Review
- Type 2 Inflammatory Responses in Autoimmune Demyelination of the Central Nervous System: Recent Advances.Journal of immunology research · 2019Review
- Mast cells regulate CD4The Journal of allergy and clinical immunology · 2018Article
- Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency.Frontiers in immunology · 2018Article
- Role of Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.Clinical reviews in allergy & immunology · 2017Review
- Treatment with anti-FcεRIα antibody exacerbates EAE and T-cell immunity against myelin.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- c-kit plays a critical role in induction of intravenous tolerance in experimental autoimmune encephalomyelitis.Immunologic research · 2015Article
- Approaches for analyzing the roles of mast cells and their proteases in vivo.Advances in immunology · 2015Review
- Receptor Tyrosine Kinase and Tyrosine Kinase Inhibitors: New Hope for Success in Multiple Sclerosis Therapy.Innovations in clinical neuroscience · 2014Review
- The significance of matrix metalloproteinases in the immunopathogenesis and treatment of multiple sclerosis.Sultan Qaboos University medical journal · 2014Review
- Protective and pathological roles of mast cells and basophils.Nature reviews. Immunology · 2013Review
- New models for analyzing mast cell functions in vivo.Trends in immunology · 2012Review
- Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis.Journal of the American Society of Nephrology : JASN · 2012Article
- Mast cells in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis.International journal of molecular sciences · 2012Review
- Mast cells: an expanding pathophysiological role from allergy to other disorders.Naunyn-Schmiedeberg's archives of pharmacology · 2012Review
- Innate immunity in the central nervous system.The Journal of clinical investigation · 2012Review
- Bystander-mediated stimulation of proteolipid protein-specific regulatory T (Treg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-β.Journal of neuroimmunology · 2012Article
- The immunologic revolution: photoimmunology.The Journal of investigative dermatology · 2012Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Mast cells (MCs) have been thought to play a pathogenic role in the development of autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. However, an immunoregulatory function of these cells has recently been suggested. We investigated the role of MCs in EAE using the W(-sh) mouse strain, which is MC deficient. W(-sh) mice developed earlier and more severe clinical and pathological disease with extensive demyelination and inflammation in the CNS. The inflammatory cells were mainly composed of CD4(+) T cells, monocyte/macrophages, neutrophils, and dendritic cells. Compared with wild-type mice, MC-deficient mice exhibited an increased level of MCP-1/CCR2 and CD44 expression on CD4(+) T cells in addition to decreased production of regulatory T cells, IL-4, IL-5, IL-27, and IL-10. We also found that levels of IL-17, IFN-γ, and GM-CSF were significantly increased in peripheral lymphocytes from immunized W(-sh) mice compared with those in peripheral lymphocytes from wild-type mice. Reconstitution of W(-sh) mice downregulated susceptibility to EAE, which correlated with MC recruitment and regulatory T cell activation in the CNS. These findings indicate that responsiveness is not required in the pathogenesis of inflammatory demyelination in the CNS and that, in the absence of MCs, increased MCP-1, CCR2, IL-17, IFN-γ, CD44, and other inflammatory molecules may be responsible for increased severity of EAE.
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