ReviewSleep medicine2011
The impact of atypical antipsychotic use on obstructive sleep apnea: a pilot study and literature review.
Review in Sleep medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Prevalence and predictors of obstructive sleep apnea in patients with bipolar disorder: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Approach the Patient With Obstructive Sleep Apnea and Obesity.The Journal of clinical endocrinology and metabolism · 2024Article
- Assessing the causal relationship between psychiatric disorders and obstructive sleep apnea: a bidirectional Mendelian randomization.Frontiers in psychiatry · 2024Article
- Profile of sleep disturbances in patients with recurrent depressive disorder or bipolar affective disorder in a tertiary sleep disorders service.Scientific reports · 2023Article
- [Sleep medicine in psychiatry and psychotherapy].Der Nervenarzt · 2022Article
- Risk of obstructive sleep apnea in patients with schizophrenia: a nationwide population-based cohort study.Social psychiatry and psychiatric epidemiology · 2020Article
- Sleep therapeutics and neuropsychiatric illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Causes of death in Prader-Willi syndrome: lessons from 11 years' experience of a national reference center.Orphanet journal of rare diseases · 2019Observational
- Benefit of continuous positive airway pressure on work quality in patients with severe obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2019Article
- [Prevalence of sleep-related breathing disorders of inpatients with psychiatric disorders].Der Nervenarzt · 2018Article
- A weight-independent association between atypical antipsychotic medications and obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2018Observational
- Risk Factors for Obstructive Sleep Apnea Are Prevalent in People with Psychosis and Correlate with Impaired Social Functioning and Poor Physical Health.Frontiers in psychiatry · 2016Article
- Risk of obstructive sleep apnoea syndrome among in-patients at a neuropsychiatric hospital in Nigeria: a short report.African health sciences · 2015Article
- Obstructive sleep apnea: management considerations in psychiatric patients.Neuropsychiatric disease and treatment · 2015Review
- Is obstructive sleep apnea the missing link between metabolic syndrome and second-generation antipsychotics: Preliminary study.Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundLimited evidence links atypical antipsychotics (AAs) use to sleep related respiratory dysfunction and greater severity of obstructive sleep apnea (OSA). The present paper reviews the published evidence and examines the impact of AA use on the presence and severity of OSA among subjects with clinically suspected OSA after adjusting for several confounds.
methodsArchives of the University of Iowa Sleep Laboratory from 2005 to 2009 were searched for patients using AAs at the time of diagnostic polysomnogram (PSG). PSG data of the 84 AA users with heterogeneous psychiatric disorders (of these 20 diagnosed only with depression) were subsequently compared to PSG data of two randomly selected, non-AA user groups from the same patient pool: (i) 200 subjects with a depressive disorder as the only psychiatric diagnosis, and (ii) 331 mentally healthy controls. PSG data were analyzed adjusting for known demographic, medical, and psychiatric risk factors for OSA.
resultsPrevalence and severity of OSA did not differ significantly across three groups. Sex, age, body mass index (BMI), and neck circumference (NC) independently predicted OSA. Odds ratio for OSA in the subset of AA users carrying the diagnosis of depression (n=20) compared with subjects without mental illness was 4.53 (p<.05). By contrast, AA users without depression or those with multiple psychiatric diagnoses including depression did not show a statistically significantly elevated OSA risk.
conclusionsAA use in subjects with depression appears to increase the risk of OSA after controlling for known predisposing factors.
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