ArticleBMC proceedings2011
Down-regulation of promoter methylation level of CD4 gene after MDV infection in MD-susceptible chicken line.
Article in BMC proceedings, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Epigenetic Factor MicroRNAs Likely Mediate Vaccine Protection Efficacy against Lymphomas in Response to Tumor Virus Infection in Chickens through Target Gene Involved Signaling Pathways.Veterinary sciences · 2024Article
- Flow cytometric evaluation of CD4Veterinary world · 2023Article
- Association of Aberrant DNA Methylation Level in theAnimals : an open access journal from MDPI · 2021Article
- Differential DNA Methylation and Gene Expression Between ALV-J-Positive and ALV-J-Negative Chickens.Frontiers in veterinary science · 2021Article
- Correlation analyses of CpG island methylation of cluster of differentiation 4 protein with gene expression and T lymphocyte subpopulation traits.Asian-Australasian journal of animal sciences · 2018Article
- Gga-miR-130b-3p inhibits MSB1 cell proliferation, migration, invasion, and its downregulation in MD tumor is attributed to hypermethylation.Oncotarget · 2018Article
- Measuring Animal Age with DNA Methylation: From Humans to Wild Animals.Frontiers in genetics · 2017Review
- Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.PLoS genetics · 2015Article
- DNA methylation and regulation of the CD8A after duck hepatitis virus type 1 infection.PloS one · 2014Article
- Gene expression and DNA methylation status of chicken primordial germ cells.Molecular biotechnology · 2013Article
- DNMT gene expression and methylome in Marek's disease resistant and susceptible chickens prior to and following infection by MDV.Epigenetics · 2013Article
- DNA Methylation Fluctuation Induced by Virus Infection Differs between MD-resistant and -susceptible Chickens.Frontiers in genetics · 2012Article
- Histone methylation analysis and pathway predictions in chickens after MDV infection.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMarek's disease virus (MDV) is an oncovirus that induces lymphoid tumors in susceptible chickens, and may affect the epigenetic stability of the CD4 gene. The purpose of this study was to find the effect of MDV infection on DNA methylation status of the CD4 gene differed between MD-resistant (L63) and -susceptible (L72) chicken lines.
methodsChickens from each line were divided into two groups with one group infected by MDV and the other group as uninfected controls. Then, promoter DNA methylation levels of the CD4 gene were measured by Pyrosequencing; and gene expression analysis was performed by quantitative PCR.
resultsPromoter methylation of the CD4 gene was found to be down-regulated in L72 chickens only after MDV infection. The methylation down-regulation of the CD4 promoter is negatively correlated with up-regulation of CD4 gene expression in the L72 spleen at 21 dpi.
conclusionsThe methylation fluctuation and mRNA expression change of CD4 gene induced by MDV infection suggested a unique epigenetic mechanism existed in MD-susceptible chickens.
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Registered trials
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