ArticleBMC proceedings2011
Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens.
Article in BMC proceedings, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 101 citations in OpenAlex.
- Comparative evaluation of a novel phytochemical mixture and monensin on host- and pathogen-targeted strategies in broiler chickens challenged with Eimeria maxima.Poultry science · 2026Article
- Gut health modulation through phytogenics in poultry: mechanisms, benefits, and applications.Frontiers in veterinary science · 2025Review
- Prophylactic and Therapeutic Efficacy of Ultrasonicated Rosmarinus officinalis Ethanolic Extract and its Chitosan-Loaded Nanoparticles Against Eimeria tenella Infected Broiler Chickens.Acta parasitologica · 2024Article
- Dietary encapsulated fennel seed (Foeniculum vulgare Mill.) essential oil supplementation improves performance, modifies the intestinal microflora, morphology, and transcriptome profile of broiler chickens.Journal of animal science · 2024Article
- Plant essential oils improve growth performance by increasing antioxidative capacity, enhancing intestinal barrier function, and modulating gut microbiota in Muscovy ducks.Poultry science · 2023Article
- Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects.Veterinary sciences · 2023Review
- Effect of Oregano Essential Oil Combined with Live and Killed Newcastle Disease Vaccines on Immune Response in Broilers Chicks in Erbil, Iraq: A Comparative Study.Archives of Razi Institute · 2022Article
- Microbiota and Transcriptomic Effects of an Essential Oil Blend and Its Delivery Route Compared to an Antibiotic Growth Promoter in Broiler Chickens.Microorganisms · 2022Article
- Avian Cell Culture Models to Study Immunomodulatory Properties of Bioactive Products.Animals : an open access journal from MDPI · 2022Review
- Phytochemical control of poultry coccidiosis: a review.Poultry science · 2022Review
- Phytogenics and encapsulated sodium butyrate can replace antibiotics as growth promoters for lightly weaned piglets.PloS one · 2022Article
- Thymol and carvacrol supplementation in poultry health and performance.Veterinary medicine and science · 2022Review
- Cinnamon: A Natural Feed Additive for Poultry Health and Production-A Review.Animals : an open access journal from MDPI · 2021Review
- Egg Quality Parameters, Production Performance and Immunity of Laying Hens Supplemented with Plant Extracts.Animals : an open access journal from MDPI · 2021Article
- Free and Microencapsulated Essential Oils Incubated In Vitro: Ruminal Stability and Fermentation Parameters.Animals : an open access journal from MDPI · 2021Article
- Article
- The effect of sodium bisulfate and coccidiostat on intestinal lesions and growth performance of Eimeria spp.-challenged broilers.Poultry science · 2020Article
- Effects of Dietary Quebracho Tannin on Performance Traits and Parasite Load in an Italian Slow-Growing Chicken (White Livorno Breed).Animals : an open access journal from MDPI · 2020Article
- Dietary phytonutrients and animal health: regulation of immune function during gastrointestinal infections.Journal of animal science · 2020Review
- Nutrigenomics in livestock-recent advances.Journal of applied genetics · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study was conducted to investigate the effects of dietary plant-derived phytonutrients, carvacrol, cinnamaldehyde and Capsicum oleoresin, on the translational regulation of genes associated with immunology, physiology and metabolism using high-throughput microarray analysis and in vivo disease challenge model of avian coccidiosis.
methodsIn this study, we used nutrigenomics technology to investigate the molecular and genetic mechanisms of dietary modulation of host innate immunity and metabolism by three phytonutrients. To validate their immunomodulatory effects in a disease model, young broiler chickens fed a standard diet supplemented with three phytochemicals (carvacrol, cinnamaldehyde, and Capsicum oleoresin) from one day post-hatch were orally challenged with E. acervulina. The body weight gain and fecal oocyst production were used to evaluate coccidiosis disease parameters.
resultsAnalysis of global gene expression profiles of intestinal tissues from phytonutrient-fed birds indicated that Capsicum oleoresin induced the most gene changes compared to the control group where many of these genes were associated with those of metabolism and immunity. The most reliable network induced by dietary cinnamaldehyde treatment was related with the functions of antigen presentation, humoral immune response, and inflammatory disease. Furthermore, dietary supplementation with these phytonutrients significantly protected broiler chickens against live coccidiosis challenge infection based on body weight and parasite fecundity.
conclusionsThe results of this study provide clear evidence to support the idea that plant-derived phytochemicals possess immune-enhancing properties in chickens and these new findings create a new possibility to develop effective drug-free alternative strategies for disease control for poultry infectious diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.