ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
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- Expression of a human variant of CHMP2B linked to neurodegeneration in Drosophila external sensory organs leads to cell fate transformations associated with increased Notch activity.Developmental neurobiology · 2020Article
- A Functional Analysis of theG3 (Bethesda, Md.) · 2020Article
- Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers.Neuron · 2016Article
- Controlled expression of Drosophila homeobox loci using the Hostile takeover system.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The transcription factor D-Pax2 is required for the correct differentiation of several cell types in Drosophila sensory systems. While the regulation of its expression in the developing eye has been well studied, little is known about the mechanisms by which the dynamic pattern of D-Pax2 expression in the external sensory organs is achieved. Here we demonstrate that early activation of D-Pax2 in the sensory organ lineage and its maintenance in the trichogen and thecogen cells are governed by separate enhancers. Furthermore, the initial activation is controlled in part by proneural proteins whereas the later maintenance expression is regulated by a positive feedback loop.
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