ArticleVirus genes2011
Genetic diversity and positive selection analysis of classical swine fever virus isolates in south China.
Article in Virus genes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Global prevalence of classical swine fever in domestic pigs: an integrative systematic review and meta-analysis.Tropical animal health and production · 2026Pooled it
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- Genetic analyses of the structural protein E2 bovine viral diarrhea virus isolated from dairy cattle in Yogyakarta, Indonesia.Veterinary world · 2024Article
- A Comprehensive Review of Our Understanding and Challenges of Viral Vaccines against Swine Pathogens.Viruses · 2024Review
- The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever.Viruses · 2022Article
- Complete genome sequences of classical swine fever virus: Phylogenetic and evolutionary analyses.Frontiers in microbiology · 2022Article
- Characterization of monoclonal antibodies that specifically differentiate field isolates from vaccine strains of classical swine fever virus.Frontiers in immunology · 2022Article
- Article
- Genotyping and Molecular Characterization of Classical Swine Fever Virus Isolated in China during 2016-2018.Viruses · 2021Article
- A Critical Review about Different Vaccines against Classical Swine Fever Virus and Their Repercussions in Endemic Regions.Vaccines · 2021Review
- Genomic characteristics of classical swine fever virus strains of bovine origin according to primary and secondary sequence-structure analysis.Open veterinary journal · 2020Article
- Complete genomic characteristics and pathogenic analysis of the newly emerged classical swine fever virus in China.BMC veterinary research · 2018Article
- Genetic Diversity and Positive Selection Analysis of Classical Swine Fever Virus Envelope Protein Gene E2 in East China under C-Strain Vaccination.Frontiers in microbiology · 2016Article
- Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs.Veterinary research · 2015Article
- Review
- Postnatal persistent infection with classical Swine Fever virus and its immunological implications.PloS one · 2015Article
- Extensive homologous recombination in classical swine fever virus: A re-evaluation of homologous recombination events in the strain AF407339.Saudi journal of biological sciences · 2014Article
- Evidence of selection pressures of neuraminidase gene (NA) of influenza A virus subtype H5N1 on different hosts in Guangxi Province of China.Saudi journal of biological sciences · 2014Article
- Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces.Journal of virology · 2012Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical swine fever virus (CSFV) causes a highly contagious disease that leads to significant economic losses in the pig industry worldwide. However, there is a paucity of knowledge on the accurate genotyping of CSFV isolates in south China. This study genotyped the E2 gene of 14 CSFV strains isolated during 2008-2010 from domestic pigs in different districts of south China. Phylogenetic analyses revealed that all of the 14 CSFV isolates were clustered into genetic subgroup 1.1. This contrasts with most parts of China, where group 2 isolates are predominant. Furthermore, the positive selection pressures acting on the E(rns) and E2 envelope protein genes of CSFV were assessed and a site-by-site analysis of the dN/dS ratio was performed to identify specific codons that undergo diversification under positive selection. While no significant evidence for positive selection was observed in E(rns), two positively selected sites at amino acid residues 49 and 72 in the E2 encoding region were identified. Our results revealed that a predominance of subgroup 1.1 CSFV isolates is currently circulating in some districts of south China, which appear to be unrelated to the Chinese C-strain vaccine. Moreover, the envelope protein gene, E2, has undergone positive selection in 14 CSFV strains and two positively selected sites have been identified in this study. Understanding the molecular epidemiology and functional importance of these positively selected amino acid positions could help to predict possible changes in virulence, the development of vaccines and disease control.
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