SynthesisMolecular biology reports2012
MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.
Synthesis in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 8 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 8 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.Medicine · 2020Pooled it
- Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2020Pooled it
- Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Pooled it
- MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis.PloS one · 2017Pooled it
- Role of genetic mutations in folate-related enzyme genes on Male Infertility.Scientific reports · 2015Pooled it
- MTHFR 677C>T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies.PloS one · 2015Pooled it
- Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.PloS one · 2013Pooled it
- Exploring Single-Nucleotide Polymorphisms in Primary and Secondary Male Infertility.Medical sciences (Basel, Switzerland) · 2025Article
- MTHFR Gene-Polymorphism and Infertile Men in Indian Population: A Systematic Literature Review.Cureus · 2022Review
- Explore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension.PPAR research · 2022Article
- Association of paternal MTHFR polymorphisms (C677T) with clinical outcomes in ICSI treatment.Frontiers in endocrinology · 2022Article
- Methylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patients.Journal of clinical laboratory analysis · 2021Article
- Synergistic effects of TIMP2-418G/C and MMP9-1562C/T variants on the male infertility risk.Molecular biology reports · 2019Article
- Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review.International journal of reproductive biomedicine · 2018Review
- Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population.Journal of assisted reproduction and genetics · 2015Article
- Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphism in Iranian Women With Idiopathic Recurrent Pregnancy Losses.Iranian Red Crescent medical journal · 2014Article
- Spectrum of MTHFR gene SNPs C677T and A1298C: a study among 23 population groups of India.Molecular biology reports · 2012Article
- No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis.Experimental and therapeutic medicine · 2012Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have evaluated the association between MTHFR 677C>T and 1298A>C polymorphisms and risk of male infertility. However, the results from the published studies on the association between these two MTHFR polymorphisms and male infertility risk are conflicting. To derive a more precise estimation of association between the MTHFR polymorphisms and risk of male infertility, we performed a meta-analysis. A comprehensive search was conducted to identify all case-control studies of MTHFR polymorphisms and male infertility risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, we found that both 677C>T and 1298A>C polymorphisms were not significantly associated with male infertility risk. However, in stratified analysis by ethnicity, we found that the 677C>T polymorphism was significantly associated with the risk of male infertility in Asian population (TT vs. CC: OR = 1.57, 95% CI: 1.05-2.37, P = 0.03; TT vs. TC + CC: OR = 1.40, 95% CI: 1.05-1.86, P = 0.02; TT + TC vs. CC: OR = 1.34, 95% CI: 1.01-1.77, P = 0.04). Although some modest bias could not be eliminated, this meta-analysis suggested that the MTHFR 677T allele might be a low-penetrant risk factor for male infertility, especially in Asian population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.