ArticleMolecular biology reports2012
EGY2, a chloroplast membrane metalloprotease, plays a role in hypocotyl elongation in Arabidopsis.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- The Involvement of thePlants (Basel, Switzerland) · 2025Article
- S2P2-the chloroplast-located intramembrane protease and its impact on the stoichiometry and functioning of the photosynthetic apparatus ofFrontiers in plant science · 2024Article
- Genome-wide association analysis identified molecular markers and candidate genes for flower traits in Chinese orchid (Horticulture research · 2023Article
- Chloroplast proteostasis: A story of birth, life, and death.Plant communications · 2023Review
- Plant protease as regulator and signaling molecule for enhancing environmental stress-tolerance.Plant cell reports · 2021Review
- An Argon-Ion-Induced Pale Green Mutant ofPlants (Basel, Switzerland) · 2021Article
- A Putative Chloroplast Thylakoid Metalloprotease VIRESCENT3 Regulates Chloroplast Development in Arabidopsis thaliana.The Journal of biological chemistry · 2016Article
- Sll0528, a Site-2-Protease, Is Critically Involved in Cold, Salt and Hyperosmotic Stress Acclimation of Cyanobacterium Synechocystis sp. PCC 6803.International journal of molecular sciences · 2014Article
- Influence of plastids on light signalling and development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis.Plant physiology · 2013Article
- Bioanalysis of eukaryotic organelles.Chemical reviews · 2013Review
- An Arabidopsis rhomboid protease has roles in the chloroplast and in flower development.Journal of experimental botany · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intramembrane proteases control many important processes in a wide variety of organisms through regulated intramembrane proteolysis (RIP). However, very few intramembrane proteases have been characterized in plants. Intriguingly, EGY2 in Arabidopsis belongs to the Site-2 protease (S2P) family that performs RIP. It contains the conserved catalytic motifs, HExxH and NPDG on its multiple transmembrane helices. Four egy2 knockout mutants have significantly shorter hypocotyls and accumulate lower levels of fatty acids in seedlings. Accumulation of fatty acid biosynthesis enzymes in seedlings are also decreased in egy2 knockout mutants. EGY2 protein resides in the chloroplast and EGY2 transcripts are found throughout the plant except root. Recombinant EGY2 protein cleaves β-casein in an ATP-independent manner. These results together suggest that EGY2 metalloprotease plays a role in hypocotyl elongation likely through a RIP dependent process to regulate the coordinated expression of nuclear- and plastid-encoded genes.
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