ArticleCoordination chemistry reviews2011
Metal Complexes for DNA-Mediated Charge Transport.
Article in Coordination chemistry reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 150 citations in OpenAlex.
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- Charge transport in individual short base stacked single-stranded RNA molecules.Scientific reports · 2023Article
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- A study of structure-activity relationship and anion-controlled quinolinyl Ag(I) complexes as antimicrobial and antioxidant agents as well as their interaction with macromolecules.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action.Molecules (Basel, Switzerland) · 2021Review
- Bis(2,2'-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator?Materials (Basel, Switzerland) · 2020Article
- Understanding the electronic properties of single- and double-stranded DNA.The European physical journal. E, Soft matter · 2020Article
- Graphene quantum dots mediated electron transfer in DNA base pairs.RSC advances · 2019Article
- Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives.Molecules (Basel, Switzerland) · 2018Review
- Photochemically active DNA-intercalating ruthenium and related complexes - insights by combining crystallography and transient spectroscopy.Chemical science · 2017Article
- N7-(carboxymethyl)guanine-Lithium Crystalline Complex: A Bioinspired Solid Electrolyte.Scientific reports · 2016Article
- Conformational gating of DNA conductance.Nature communications · 2015Article
- Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex.Angewandte Chemie (International ed. in English) · 2015Article
- Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy.Coordination chemistry reviews · 2015Article
- Article
- Long-range electron tunneling.Journal of the American Chemical Society · 2014Article
- Redox mediators in visible light photocatalysis: photocatalytic radical thiol-ene additions.The Journal of organic chemistry · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In all organisms, oxidation threatens the integrity of the genome. DNA-mediated charge transport (CT) may play an important role in the generation and repair of this oxidative damage. In studies involving long-range CT from intercalating Ru and Rh complexes to 5'-GG-3' sites, we have examined the efficiency of CT as a function of distance, temperature, and the electronic coupling of metal oxidants bound to the base stack. Most striking is the shallow distance dependence and the sensitivity of DNA CT to how the metal complexes are stacked in the helix. Experiments with cyclopropylamine-modified bases have revealed that charge occupation occurs at all sites along the bridge. Using Ir complexes, we have seen that the process of DNA-mediated reduction is very similar to that of DNA-mediated oxidation. Studies involving metalloproteins have, furthermore, shown that their redox activity is DNA-dependent and can be DNA-mediated. Long range DNA-mediated CT can facilitate the oxidation of DNA-bound base excision repair proteins to initiate a redox-active search for DNA lesions. DNA CT can also activate the transcription factor SoxR, triggering a cellular response to oxidative stress. Indeed, these studies show that within the cell, redox-active proteins may utilize the same chemistry as that of synthetic metal complexes in vitro, and these proteins may harness DNA-mediated CT to reduce damage to the genome and regulate cellular processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.