ArticleJournal of statistical physics2011
Quantifying information transmission in eukaryotic gradient sensing and chemotactic response.
Article in Journal of statistical physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Information bounds on the accuracy of cell polarization.PloS one · 2025Article
- Decoding the chemotactic signal.Journal of leukocyte biology · 2018Review
- Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- High fidelity information processing in folic acid chemotaxis of Dictyostelium amoebae.Journal of the Royal Society, Interface · 2013Article
- Systems biology: the role of engineering in the reverse engineering of biological signaling.Cells · 2013Article
- How input fluctuations reshape the dynamics of a biological switching system.Physical review. E, Statistical, nonlinear, and soft matter physics · 2012Article
- A framework for designing and analyzing binary decision-making strategies in cellular systems.Integrative biology : quantitative biosciences from nano to macro · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Eukaryotic cells are able to sense shallow chemical gradients by surface receptors and migrate toward chemoattractant sources. The accuracy of this chemotactic response relies on the ability of cells to infer gradients from the heterogeneous distribution of receptors bound by diffusing chemical molecules. Ultimately, the precision of gradient sensing is limited by the fluctuations of signaling components, including the stochastic receptor occupancy and noisy intracellular processing. Viewing the system as a Markovian communication channel, we apply techniques from information theory to derive upper bounds on the amount of information that can be reliably transmitted through a chemotactic cell. Specifically, we derive an expression for the mutual information between the gradient direction and the spatial distribution of bound receptors. We also compute the mutual information between the gradient direction and the motility direction using three different models for cell motion. Our results can be used to quantify the information loss during the various stages of directional sensing in eukaryotic chemotaxis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.