ArticleCrystal growth & design2011
What's in a drop? Correlating observations and outcomes to guide macromolecular crystallization experiments.
Article in Crystal growth & design, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed.
- Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation.IUCrJ · 2026Article
- Crystal engineering of the hepatoma-derived growth factor-related protein 2 PWWP domain towards crystallographic fragment screening.Acta crystallographica. Section F, Structural biology communications · 2025Article
- Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- TAAM refinement on high-resolution experimental and simulated 3D ED/MicroED data for organic molecules.Acta crystallographica. Section C, Structural chemistry · 2024Article
- Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions.bioRxiv : the preprint server for biology · 2024Article
- Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution.Protein science : a publication of the Protein Society · 2024Article
- 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening.Acta crystallographica. Section D, Structural biology · 2023Article
- Self-Assembly of Tunable Intrinsically Disordered Peptide Amphiphiles.Biomacromolecules · 2023Article
- Machine learning-based protein crystal detection for monitoring of crystallization processes enabled with large-scale synthetic data sets of photorealistic images.Analytical and bioanalytical chemistry · 2022Article
- MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.Nature communications · 2021Article
- MicroED in natural product and small molecule research.Natural product reports · 2021Review
- Macromolecular crystallography using microcrystal electron diffraction.Acta crystallographica. Section D, Structural biology · 2021Review
- Cinder: keeping crystallographers app-y.Acta crystallographica. Section F, Structural biology communications · 2018Article
- The use of haptic interfaces and web services in crystallography: an application for a 'screen to beam' interface.Journal of applied crystallography · 2016Article
- Computational crystallization.Archives of biochemistry and biophysics · 2016Review
- Minimal physical requirements for crystal growth self-poisoning.The Journal of chemical physics · 2016Article
- Analysis of crystallization data in the Protein Data Bank.Acta crystallographica. Section F, Structural biology communications · 2015Article
- The detection and subsequent volume optimization of biological nanocrystals.Structural dynamics (Melville, N.Y.) · 2015Article
- Using isoelectric point to determine the pH for initial protein crystallization trials.Bioinformatics (Oxford, England) · 2015Article
- Sparse and incomplete factorial matrices to screen membrane protein 2D crystallization.Journal of structural biology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Observations of crystallization experiments are classified as specific outcomes and integrated through a phase diagram to visualize solubility and thereby direct subsequent experiments. Specific examples are taken from our high-throughput crystallization laboratory which provided a broad scope of data from 20 million crystallization experiments on 12,500 different biological macromolecules. The methods and rationale are broadly and generally applicable in any crystallization laboratory. Through a combination of incomplete factorial sampling of crystallization cocktails, standard outcome classifications, visualization of outcomes as they relate chemically and application of a simple phase diagram approach we demonstrate how to logically design subsequent crystallization experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.