ReviewNature reviews. Gastroenterology & hepatology2011
Influence of obesity on the risk of esophageal disorders.
Review in Nature reviews. Gastroenterology & hepatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 5 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Evaluating the effect of cigarettes smoking on oesophageal cancer risk: a systematic review and meta-analysis with dose-response relationships.European journal of public health · 2026Pooled it
- Adiposity and cancer: systematic review and meta-analysis.Nature metabolism · 2026Pooled it
- Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies.Bioscience reports · 2017Pooled it
- Obesity survival paradox in pneumonia: a meta-analysis.BMC medicine · 2014Pooled it
- Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Pooled it
- Hewei Jiangni recipe improved the quality of life in patients with cold-heat mixed nonerosive reflux disease: a randomized, double-blinded study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Trial
- GERD in elderly patients: surgical treatment with Nissen-Rossetti laparoscopic technique, outcome.BMC surgery · 2012Trial
- Reply to: Comments on "Meat Intake and Risk of Gastric and Esophageal Adenocarcinoma in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study".International journal of cancer · 2026Article
- Associations Between Non-Genetic Risk Factors and DNA Methylation Alterations in Barrett's Esophagus and Its Progression to Esophageal Adenocarcinoma.International journal of molecular sciences · 2025Review
- Incidence trends of esophageal squamous cell and adenocarcinoma in Finland in 2000-2021.Acta oncologica (Stockholm, Sweden) · 2025Article
- The Economic Impact of Introducing RefluxStop for Refractory Gastroesophageal Reflux Disease on the Italian Healthcare System.PharmacoEconomics - open · 2024Article
- Causal effects of genetic birth weight and gestational age on adult esophageal diseases: Mendelian randomization study.World journal of gastrointestinal oncology · 2024Article
- 25 year trends in cancer incidence and mortality among adults aged 35-69 years in the UK, 1993-2018: retrospective secondary analysis.BMJ (Clinical research ed.) · 2024Article
- Genetically predicted 486 blood metabolites in relation to risk of esophageal cancer: a Mendelian randomization study.Frontiers in molecular biosciences · 2024Article
- Cholelithiasis and cholecystectomy increase the risk of gastroesophageal reflux disease and Barrett's esophagus.Frontiers in medicine · 2024Article
- Adiposity and risk of oesophageal cancer subtypes in the Million Women Study.International journal of epidemiology · 2023Article
- Body mass index and esophageal and gastric cancer: A pooled analysis of 10 population-based cohort studies in Japan.Cancer science · 2023Article
- Updated epidemiology of gastrointestinal cancers in East Asia.Nature reviews. Gastroenterology & hepatology · 2023Review
- Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study.British journal of cancer · 2023Article
- The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is associated with an increased risk of esophageal disorders, including esophageal adenocarcinoma, Barrett esophagus and GERD. For reasons yet unknown, the association between obesity and esophageal adenocarcinoma seems to be stronger than that for other types of obesity-related cancers. Predominantly abdominal or intra-abdominal adiposity (representing visceral fat and other fat within the abdominal cavity), which is more frequently observed in men than in women, is more strongly linked with these esophageal disorders than BMI alone, a finding that might contribute to the striking male predominance of esophageal adenocarcinoma. Research has identified potential mechanisms underlying the strong link between obesity and esophageal conditions. These findings are summarized in this Review, but more research remains to be carried out before these mechanisms are established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.