ReviewActa pharmacologica Sinica2011
Propofol and arrhythmias: two sides of the coin.
Review in Acta pharmacologica Sinica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Efficacy and safety of ciprofol versus propofol for anesthesia in patients undergoing gastrointestinal endoscope: a systematic review and meta-analysis of randomized controlled trials (RCT).BMC anesthesiology · 2025Pooled it
- Effective Dosage of Ciprofol for the Induction of General Anesthesia Across Diverse Age Groups in Adults: A Single-Center, Prospective, Non-Randomized Sequential Trial.Journal of pain research · 2025Trial
- Observer's Assessment of Alertness/Sedation-based titration reduces propofol consumption and incidence of hypotension during general anesthesia induction: A randomized controlled trial.Science progress · 2021Trial
- Hemodynamic impact of increasing time between fentanyl and propofol administration during anesthesia induction: a randomised, clinical trial.Brazilian journal of anesthesiology (Elsevier)Trial
- Perioperative Arrhythmias: Pathophysiology, Risk Stratification, Management, and Emerging Technologies-A Narrative Review Toward Personalised Care.Journal of personalized medicine · 2026Review
- Ultrasound-Guided Regional Anesthesia for Repeat Ventricular Arrhythmia Catheter Ablation: A Case Report.Cureus · 2025Article
- Clinical Use of Fospropofol Disodium: Evaluation of Pharmacology, Safety, and Efficacy.Drug design, development and therapy · 2025Review
- To cool or not to cool: Targeted temperature management to prevent ventricular tachycardia associated with Brugada syndrome.Clinical case reports · 2023Article
- Propofol-Related Infusion Syndrome: A Bibliometric Analysis of the 100 Most-Cited Articles.Cureus · 2023Review
- Electroanatomical Conduction Characteristics of Pig Myocardial Tissue Derived from High-Density Mapping.Journal of clinical medicine · 2023Article
- Organization of atrial fibrillation using a pure sodium channel blocker: Implications of rotor ablation therapy.Journal of arrhythmia · 2023Article
- Review
- Contemporary management of ventricular electrical storm in Europe: results of a European Heart Rhythm Association Survey.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Myocardial oxidative stress is increased in early reperfusion, but systemic antioxidative therapy does not prevent ischemia-reperfusion arrhythmias in pigs.Frontiers in cardiovascular medicine · 2023Article
- Article
- Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?BioMed research international · 2023Review
- Prolonged asystole induced by trigeminocardiac reflex accompanied with abnormal heart rate variability during percutaneous balloon compression: a case report.The Journal of international medical research · 2023Article
- Comparison of the effects of propofol and alfaxalone on the electrocardiogram of dogs, with particular reference to QT interval.Frontiers in veterinary science · 2023Article
- Accelerated Idioventricular Rhythm Following Intraoral Local Anesthetic Injection During General Anesthesia.Anesthesia progress · 2021Article
- Arrhythmias in COVID-19.Methodist DeBakey cardiovascular journal · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The hypnotic agent propofol is effective for the induction and maintenance of anesthesia. However, recent studies have shown that propofol administration is related to arrhythmias. Propofol displays both pro- and anti-arrhythmic effects in a concentration-dependent manner. Data indicate that propofol can convert supraventricular tachycardia and ventricular tachycardia and may inhibit the conduction system of the heart. The mechanism of the cardiac effects remains poorly defined and may involve ion channels, the autonomic nervous system and cardiac gap junctions. Specifically, sodium, calcium and potassium currents in cardiac cells are suppressed by clinically relevant concentrations of propofol. Propofol shortens the action potential duration (APD) but lessens the ischemia-induced decrease in the APD. Furthermore, propofol suppresses both sympathetic and parasympathetic tone and preserves gap junctions during ischemia. All of these effects cumulatively contribute to the antiarrhythmic and proarrhythmic properties of propofol.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.