ReviewMolecular human reproduction2011
Strategies for locating the female gamete: the importance of measuring sperm trajectories in three spatial dimensions.
Review in Molecular human reproduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Swimming by Spinning: Spinning-Top Type Rotations Regularize Sperm Swimming Into Persistently Progressive Paths in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Capacitation promotes a shift in energy metabolism in murine sperm.Frontiers in cell and developmental biology · 2022Article
- In Silico Reconstruction of Sperm Chemotaxis.International journal of molecular sciences · 2021Article
- RETRACTED: Human sperm uses asymmetric and anisotropic flagellar controls to regulate swimming symmetry and cell steering.Science advances · 2020Article
- Differences and Similarities: The Richness of Comparative Sperm Physiology.Physiology (Bethesda, Md.) · 2020Review
- Microfluidics for sperm analysis and selection.Nature reviews. Urology · 2017Review
- Plant science: Sexual attraction channelled in moss.Nature · 2017Article
- Two-dimensional slither swimming of sperm within a micrometre of a surface.Nature communications · 2015Article
- Sperm navigation along helical paths in 3D chemoattractant landscapes.Nature communications · 2015Article
- Sperm guidance to the egg finds calcium at the helm.Protoplasma · 2014Review
- T-type Ca2+ channels in spermatogenic cells and sperm.Pflugers Archiv : European journal of physiology · 2014Review
- K+ and Cl- channels and transporters in sperm function.Current topics in developmental biology · 2013Review
- High-throughput lensfree 3D tracking of human sperms reveals rare statistics of helical trajectories.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm.The Journal of cell biology · 2012Article
- Two types of assays for detecting frog sperm chemoattraction.Journal of visualized experiments : JoVE · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spermatozoon must find its female gamete partner and deliver its genetic material to generate a new individual. This requires that the spermatozoon be motile and endowed with sophisticated swimming strategies to locate the oocyte. A common strategy is chemotaxis, in which spermatozoa detect and follow a gradient of chemical signals released by the egg and its associated structures. Decoding the female gamete's positional information is a process that spermatozoa undergo in a three-dimensional (3D) space; however, due to their speed and small size, this process has been studied almost exclusively in spermatozoa restricted to swimming in two dimensions (2D). This review examines the relationship between the mechanics of sperm propulsion and the physiological function of these cells in 3D. It also considers whether it is possible to derive all the 3D sperm swimming characteristics by extrapolating from 2D measurements. It is concluded that full insight into flagellar beat dynamics, swimming paths and chemotaxis under physiological conditions will eventually require quantitative imaging of flagellar form, ion flux changes, cell trajectories and modelling of free-swimming spermatozoa in 3D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.