ArticleEukaryotic cell2011
Clustering of nuclei in multinucleated hyphae is prevented by dynein-driven bidirectional nuclear movements and microtubule growth control in Ashbya gossypii.
Article in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Signatures of gene transfer in the parallel evolution of osmotrophic specialization in eukaryotes.Nature ecology & evolution · 2026Article
- The nuclear transport factor CSE1 drives macronuclear volume increase and macronuclear node coalescence iniScience · 2023Article
- Nuclear movement in multinucleated cells.Development (Cambridge, England) · 2022Review
- Asynchronous nuclear cycles in multinucleatedScience advances · 2022Article
- Sporulation inJournal of fungi (Basel, Switzerland) · 2020Review
- Reverse-engineering forces responsible for dynamic clustering and spreading of multiple nuclei in developing muscle cells.Molecular biology of the cell · 2020Article
- Nuclear movement in fungi.Seminars in cell & developmental biology · 2018Review
- The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly.Scientific reports · 2018Article
- A nuclear contortionist: the mitotic migration ofMycology · 2018Review
- Mechanism of nuclear movements in a multinucleated cell.Molecular biology of the cell · 2017Article
- Clustered nuclei maintain autonomy and nucleocytoplasmic ratio control in a syncytium.Molecular biology of the cell · 2016Article
- Cytoplasmic dynein and early endosome transport.Cellular and molecular life sciences : CMLS · 2015Review
- FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus.Molecular biology of the cell · 2014Article
- Organization of organelles within hyphae of Ashbya gossypii revealed by electron tomography.Eukaryotic cell · 2013Article
- Nuclear repulsion enables division autonomy in a single cytoplasm.Current biology : CB · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
During filamentous fungus development, multinucleated hyphae employ a system for long-range nuclear migration to maintain an equal nuclear density. A decade ago the microtubule motor dynein was shown to play a central role in this process. Previous studies with Ashbya gossypii revealed extensive bidirectional movements and bypassings of nuclei, an autonomous cytoplasmic microtubule (cMT) cytoskeleton emanating from each nucleus, and pulling of nuclei by sliding of cMTs along the cortex. Here, we show that dynein is the sole motor for bidirectional movements and bypassing because these movements are concomitantly decreased in mutants carrying truncations of the dynein heavy-chain DYN1 promoter. The dynactin component Jnm1, the accessory proteins Dyn2 and Ndl1, and the potential dynein cortical anchor Num1 are also involved in the dynamic distribution of nuclei. In their absence, nuclei aggregate to different degrees, whereby the mutants with dense nuclear clusters grow extremely long cMTs. As in budding yeast, we found that dynein is delivered to cMT plus ends, and its activity or processivity is probably controlled by dynactin and Num1. Together with its role in powering nuclear movements, we propose that dynein also plays (directly or indirectly) a role in the control of cMT length. Those combined dynein actions prevent nuclear clustering in A. gossypii and thus reveal a novel cellular role for dynein.
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