ArticleThe Journal of biological chemistry2011
New family of deamination repair enzymes in uracil-DNA glycosylase superfamily.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- Structural and Functional Insights into UDGs.Protein and peptide letters · 2025Review
- Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos.Nature biotechnology · 2024Article
- Structural and functional coupling in cross-linking uracil-DNA glycosylase UDGX.Bioscience reports · 2024Article
- Mutational and structural analyses of UdgX: insights into the active site pocket architecture and its evolution.Nucleic acids research · 2023Article
- Biochemical and mutational studies of an endonuclease V from the hyperthermophilic crenarchaeon Sulfolobus islandicus REY15A.World journal of microbiology & biotechnology · 2023Article
- DR0022 from Deinococcus radiodurans is an acid uracil-DNA glycosylase.The FEBS journal · 2022Article
- Identification of a novel bifunctional uracil DNA glycosylase from Thermococcus barophilus Ch5.Applied microbiology and biotechnology · 2021Article
- Review
- Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea.Frontiers in microbiology · 2021Review
- Computational Study on DNA Repair: The Roles of Electrostatic Interactions Between Uracil-DNA Glycosylase (UDG) and DNA.Frontiers in molecular biosciences · 2021Article
- Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.Nature chemical biology · 2019Article
- Targeted exon skipping with AAV-mediated split adenine base editors.Cell discovery · 2019Article
- Role of endonuclease III enzymes in uracil repair.Mutation research · 2019Article
- The mesophilic archaeon Methanosarcina acetivorans counteracts uracil in DNA with multiple enzymes: EndoQ, ExoIII, and UDG.Scientific reports · 2018Article
- An unconventional family 1 uracil DNA glycosylase in Nitratifractor salsuginis.The FEBS journal · 2017Article
- Identification of a prototypical single-stranded uracil DNA glycosylase from Listeria innocua.DNA repair · 2017Article
- Uracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens: characterization of a new class of UDG with broad substrate specificity.Nucleic acids research · 2017Article
- Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily.Scientific reports · 2017Article
- Article
- Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases.Protein science : a publication of the Protein Society · 2016Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
DNA glycosylases play a major role in the repair of deaminated DNA damage. Previous investigations identified five families within the uracil-DNA glycosylase (UDG) superfamily. All enzymes within the superfamily studied thus far exhibit uracil-DNA glycosylase activity. Here we identify a new class of DNA glycosylases in the UDG superfamily that lacks UDG activity. Instead, these enzymes act as hypoxanthine-DNA glycosylases in vitro and in vivo. Molecular modeling and structure-guided mutational analysis allowed us to identify a unique catalytic center in this class of DNA glycosylases. Based on unprecedented biochemical properties and phylogenetic analysis, we propose this new class of DNA repair glycosylases that exists in bacteria, archaea, and eukaryotes as family 6 and designate it as the hypoxanthine-DNA glycosylase family. This study demonstrates the structural evolvability that underlies substrate specificity and catalytic flexibility in the evolution of enzymatic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.