Evidence map›Paper›PMID 21642384›Full record

ReviewReproduction (Cambridge, England)2011

Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles.

Antonina I Frolova, Kelle H Moley

Open access · bronzeAbstract readReview
In one paragraph

Review in Reproduction (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Glucose metabolism and endometrium decidualization.Frontiers in endocrinology · 2025
    Review
  8. Breast cancer shares many epidemiological, lifestyle, and local hormonal and metabolic underpinnings with endometrial and ovarian cancer: a narrative review.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Relevance of Sugar Transport across the Cell Membrane.International journal of molecular sciences · 2023
    Review
  16. Endometrial glycogen metabolism during early pregnancy in mice.Molecular reproduction and development · 2022
    Article
  17. Article
  18. Journal of advanced research · 2022
    Article
  19. Review
  20. Endometrial Glucose Transporters in Health and Disease.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Antonina I FrolovaDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63122, USA.
Kelle H Moley
Washington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
MOLECULAR AND METABOLIC ASPECTS OF IMPLANTATIONR01HD065435 · NICHD · WASHINGTON UNIVERSITY · PI KOMMAGANI, RAMAKRISHNA, SANTI, CELIA M · 2010 to 2020
$4.5M
SLO3 KO MOUSE: A TOOL TO REVEAL VOLTAGE-DEPENDENT PROCESSES IN SPERM FERTILITYR01HD069631 · NICHD · WASHINGTON UNIVERSITY · PI SANTI, CELIA M · 2011 to 2022
$3.3M
GLUTS AND GLUCOSE TRANSPORT IN THE MOUSE BLASTOCYSTR01HD040390 · NICHD · WASHINGTON UNIVERSITY · PI MOLEY, KELLE H · 2002 to 2012
$2.6M
Steroid regulation of glucose utilization during early pregnancy.F30DK083224 · NIDDK · WASHINGTON UNIVERSITY · PI FROLOVA, ANTONINA I · 2008 to 2010
$77k
NICHD NIH HHS R01 HD040390NICHD NIH HHS R01 HD065435NICHD NIH HHS R01HD065435NICHD NIH HHS R01 HD069631NIDDK NIH HHS F30 DK083224NIDDK NIH HHS F30DK083224NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Facilitative glucose transport molecules (glucose transporters, GLUTs) are responsible for glucose transport across cellular membranes. Of the 14 family members, expression of nine has been reported in the murine uterus and seven in the human uterus. Some studies reveal that adequate glucose uptake and metabolism are essential for the proper differentiation of the uterine endometrium toward a receptive state capable of supporting embryo implantation. However, the mechanistic role of GLUTs in endometrial function remains poorly understood. This review aims to present the current knowledge about GLUT expression in the uterus and distribution among the different cell types within the endometrium. In addition, it analyzes the available data in the context of roles GLUTs may play in normal uterine physiology as well as the pathological conditions of infertility, endometrial cancer, and polycystic ovarian syndrome.

Indexed as

AnimalsBiological TransportEmbryo ImplantationEndometrial NeoplasmsEndometriumFemaleGlucoseGlucose Transport Proteins, FacilitativeHumansInfertility, FemaleOrgan SpecificityPolycystic Ovary SyndromeProtein IsoformsSpecies SpecificityUterusGlucoseGlucose Transport Proteins, FacilitativeProtein Isoforms

Identifiers

PMID21642384
PMCPMC5028205
OpenAlexW2073312761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.