ArticleCell metabolism2011
The circadian clock interacts with metabolic physiology to influence reproductive fitness.
Article in Cell metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Guidelines for Genome-Scale Analysis of Biological Rhythms.Journal of biological rhythms · 2017Guideline
- Fat body CLOCK restrains innate immunity and maintains survival under dietary stress inbioRxiv : the preprint server for biology · 2026Article
- Glucose is dynamically regulated by time of day in humans and Drosophila.PLoS biology · 2026Article
- Increased Glycine-N-methyltransferase expression disrupts light-dependent gene expression rhythms in the Drosophila eye.Journal of cell science · 2026Article
- Artificial light at night (ALAN) negatively affects expression of transcripts involved in biosynthesis of molting and juvenile hormones in Bombyx mori.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Review
- Circadian Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Remote and partial clocks expand the circadian neuronal network, driving widespread molecular rhythmicity inbioRxiv : the preprint server for biology · 2025Article
- Tissue-specific CLOCK isoforms modulate circadian feedback loops to govern reproductive fitness in Drosophila.Cellular and molecular life sciences : CMLS · 2025Article
- Spider predatory aggressiveness exhibits diverse personality and plasticity associations and complex neurophysiological mechanisms.Scientific reports · 2025Article
- A carnitine transporter at the blood-brain barrier modulates sleep via glial lipid metabolism inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome-wide identification of PAR domain protein 1 (PDP1) targets through ChIP-seq reveals the regulation of diapause-specific characteristics in Culex pipiens.Insect molecular biology · 2024Article
- A role for the circadian photoreceptor CRYPTOCHROME in regulating triglyceride metabolism in Drosophila.G3 (Bethesda, Md.) · 2024Article
- Improvement of starvation resistance via periodic fasting is genetically variable inPhysiological entomology · 2024Article
- The Royal Zoological Society of Scotland's Approach to Assessing and Promoting Animal Welfare in Collaboration with Universities.Animals : an open access journal from MDPI · 2024Article
- Temperature-driven coordination of circadian transcriptional regulation.PLoS computational biology · 2024Article
- Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Con-DAM: Simultaneous measurement of food intake and sleep inmicroPublication biology · 2024Article
- Time is of the essence: The importance of considering biological rhythms in an increasingly polluted world.PLoS biology · 2024Article
47 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythms are regulated by a synchronized system of central and peripheral clocks. Here, we show that a clock in the Drosophila fat body drives rhythmic expression of genes involved in metabolism, detoxification, the immune response, and steroid hormone regulation. Some of these genes cycle even when the fat body clock is disrupted, indicating that they are regulated by exogenous factors. Food is an important stimulus, as limiting food availability to a 6 hr interval each day drives rhythmic expression of genes in the fat body. Restricting food to a time of day when consumption is typically low desynchronizes internal rhythms because it alters the phase of rhythmic gene expression in the fat body without affecting the brain clock. Flies maintained on this paradigm produce fewer eggs than those restricted to food at the normal time. These data suggest that desynchrony of endogenous rhythms, caused by aberrant feeding patterns, affects reproductive fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.