ReviewSeminars in perinatology2011
Newborn jaundice technologies: unbound bilirubin and bilirubin binding capacity in neonates.
Review in Seminars in perinatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02691156 (Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm Infants), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm Infants
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Fluid supplementation for neonatal unconjugated hyperbilirubinaemia.The Cochrane database of systematic reviews · 2017Pooled it
- The influencing factors of amplitude-integrated electroencephalography and bilirubin-induced neurological dysfunction scores in neonates with hyperbilirubinemia: a cross-sectional study.BMC pediatrics · 2026Article
- Article
- 175 Years of Bilirubin Testing: Ready for Point-of-Care?Advanced healthcare materials · 2023Article
- Fatty Acids and Bilirubin as Intrinsic Autofluorescence Serum Biomarkers of Drug Action in a Rat Model of Liver Ischemia and Reperfusion.Molecules (Basel, Switzerland) · 2023Article
- Effects of lipid emulsions on unbound bilirubin and response to phototherapy in preterm infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Increased Total Serum Bilirubin Level Post-Ibuprofen Use Is Inversely Correlated with Neonates' Body Weight.Children (Basel, Switzerland) · 2022Article
- Bilirubin inhibits lipid raft dependent functions of L1 cell adhesion molecule in rat pup cerebellar granule neurons.Pediatric research · 2021Article
- Newborns bilirubin concentration determined by different methods in relation to hematocrit and albumin level.Journal of medical biochemistry · 2020Article
- High unbound bilirubin for age: a neurotoxin with major effects on the developing brain.Pediatric research · 2019Review
- Bilirubin Albumin Binding and Unbound Unconjugated Hyperbilirubinemia in Premature Infants.The Journal of pediatrics · 2018Observational
- Does anaesthesia in mothers during delivery affect bilirubin levels in their neonates?Korean journal of pediatrics · 2017Article
- Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia.Pediatrics · 2017Observational
- Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus.Endocrine · 2017Article
- Bilirubin Binding Capacity in the Preterm Neonate.Clinics in perinatology · 2016Review
- Unbound unconjugated hyperbilirubinemia is associated with central apnea in premature infants.The Journal of pediatrics · 2015Article
- Autofluorescence spectroscopy and imaging: a tool for biomedical research and diagnosis.European journal of histochemistry : EJH · 2014Review
- Impact of obesity on liver function tests: is nonalcoholic fatty liver disease the only player? A review article.Porto biomedical journalReview
- Serum total bilirubin is a risk factor of metabolic syndrome and its components in obese Egyptians.Porto biomedical journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neonatal jaundice (hyperbilirubinemia), which is extremely common in neonates, can be associated with neurotoxicity. A safe level of bilirubin has not been defined in either premature or term infants. Emerging evidence suggest that the level of unbound (or "free") bilirubin has a better sensitivity and specificity than total serum bilirubin for bilirubin-induced neurotoxicity. Although recent studies suggest the usefulness of free bilirubin measurements in managing high-risk neonates, including premature infants, no widely available method exists to assay the serum free bilirubin concentration. To keep pace with the growing demand, in addition to reevaluation of old methods, several promising new methods are being developed for sensitive, accurate, and rapid measurement of free bilirubin and bilirubin binding capacity. These innovative methods need to be validated before adopting for clinical use. We provide an overview of some promising methods for free bilirubin and binding capacity measurements with the goal to enhance research in this area of active interest and apparent need.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.