ArticleAmerican heart journal2011
Depressive symptoms are related to progression of coronary calcium in midlife women: the Study of Women's Health Across the Nation (SWAN) Heart Study.
Article in American heart journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Association of Depression with Subclinical Coronary Atherosclerosis: a Systematic Review.Journal of cardiovascular translational research · 2021Pooled it
- Differential effects of hormone therapy on serotonin, vascular function and mood in the KEEPS.Climacteric : the journal of the International Menopause Society · 2016Trial
- Effect of collaborative care for depression on risk of cardiovascular events: data from the IMPACT randomized controlled trial.Psychosomatic medicine · 2014Trial
- Hormone Replacement Therapy and Cardiovascular Health in Postmenopausal Women.International journal of molecular sciences · 2025Review
- The menopausal transition period and cardiovascular risk.Nature reviews. Cardiology · 2024Review
- Psychosocial Well-Being and Progression of Coronary Artery Calcification in Midlife Women.Journal of the American Heart Association · 2022Article
- Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life.Menopause (New York, N.Y.) · 2018Article
- Adjuvant Therapy of Oral Chinese Herbal Medicine for Menopausal Depression: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Evaluating the longitudinal risk of social vigilance on atherosclerosis: study protocol for the North Texas Heart Study.BMJ open · 2017Article
- Interaction between smoking and depressive symptoms with subclinical heart disease in the Coronary Artery Risk Development in Young Adults (CARDIA) study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- Relation of Persistent Depressive Symptoms to Coronary Artery Calcification in Women Aged 46 to 59 Years.The American journal of cardiology · 2016Article
- Relation of Depressive Symptoms With Coronary Artery Calcium Determined by Electron-Beam Computed Tomography (from the Rancho Bernardo Study).The American journal of cardiology · 2016Article
- Carotid Intima-media Thickness Measurements: Relations with Atherosclerosis, Risk of Cardiovascular Disease and Application in Randomized Controlled Trials.Chinese medical journal · 2016Review
- Ambient air pollution and depressive symptoms in older adults: results from the MOBILIZE Boston study.Environmental health perspectives · 2014Article
- Association of depressive symptoms, trait anxiety, and perceived stress with subclinical atherosclerosis: results from the Chicago Healthy Aging Study (CHAS).Preventive medicine · 2014Article
- Depression increases stroke hospitalization cost: an analysis of 17,010 stroke patients in 2008 by race and gender.Stroke research and treatment · 2013Article
- Depressive symptom clusters and 5-year incidence of coronary artery calcification: the coronary artery risk development in young adults study.Circulation · 2012Article
- Epidemiology and Management of Depression Following Coronary Heart Disease Diagnosis in Women.Current cardiovascular risk reports · 2012Article
- Progression of coronary artery calcification in black and white women: do the stresses and rewards of multiple roles matter?Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2012Article
- Mood and menopause: findings from the Study of Women's Health Across the Nation (SWAN) over 10 years.Obstetrics and gynecology clinics of North America · 2011Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMajor depression and depressive symptoms are associated with cardiovascular disease (CVD), but the impact of depression on early atherogenesis is less well known, particularly in women and minorities. This study examined whether depressive symptoms are associated with progression of coronary artery calcification (CAC) among women at midlife.
methodsThe SWAN is a longitudinal, multisite study assessing health and psychologic factors in midlife women. An ancillary study (SWAN Heart) evaluated subclinical atherosclerosis in women who reported no history of CVD or diabetes. In 346 women, CAC was measured twice by electron beam computed tomography, an average of 2.3 years apart. Progression, defined as an increase by ≥10 Agatston units, was analyzed using relative risk (RR) regression. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression (CES-D) Scale.
resultsProgression of CAC was observed in 67 women (19.1%). Each 1-SD-higher CES-D score at baseline related to a 25% increased risk of CAC progression (RR 1.25, 95% CI 1.06-1.47, P = .007), adjusting for age, time between scans, ethnicity, education, menopausal status, and known CVD risk factors. This risk was similar to the risk induced by body mass index (RR 1.31, 95% CI 1.11-1.54, P = .001) and systolic blood pressure (RR 1.28, 95% CI 1.06-1.55, P = .01).
conclusionsDepressive symptoms were independently associated with progression of CAC in this cohort of midlife women. Depressive symptoms may represent a risk factor that is potentially modifiable for early prevention of CVD in women.
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