ArticleBiophysical journal2011
Linker histones incorporation maintains chromatin fiber plasticity.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Modelling and DNA topology of compact 2-start and 1-start chromatin fibres.Nucleic acids research · 2019Article
- The regulatory role of DNA supercoiling in nucleoprotein complex assembly and genetic activity.Biophysical reviews · 2016Review
- Supercoiling biases the formation of loops involved in gene regulation.Biophysical reviews · 2016Review
- A metastable structure for the compact 30-nm chromatin fibre.FEBS letters · 2016Article
- Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains.BMC genomics · 2015Article
- Torsional behavior of chromatin is modulated by rotational phasing of nucleosomes.Nucleic acids research · 2014Article
- DNA topology in chromosomes: a quantitative survey and its physiological implications.Journal of mathematical biology · 2014Article
- Histone H1 compacts DNA under force and during chromatin assembly.Molecular biology of the cell · 2012Article
- Distinct contributions of MSL complex subunits to the transcriptional enhancement responsible for dosage compensation in Drosophila.Nucleic acids research · 2012Article
- On the topology of chromatin fibres.Interface focus · 2012Article
- The importance of being supercoiled: how DNA mechanics regulate dynamic processes.Biochimica et biophysica acta · 2012Review
- Recent advances in single molecule studies of nucleosomes.Current opinion in structural biology · 2012Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic DNA in eukaryotic cells is organized in supercoiled chromatin fibers, which undergo dynamic changes during such DNA metabolic processes as transcription or replication. Indeed, DNA-translocating enzymes like polymerases produce physical constraints in vivo. We used single-molecule micromanipulation by magnetic tweezers to study the response of chromatin to mechanical constraints in the same range as those encountered in vivo. We had previously shown that under positive torsional constraints, nucleosomes can undergo a reversible chiral transition toward a state of positive topology. We demonstrate here that chromatin fibers comprising linker histones present a torsional plasticity similar to that of naked nucleosome arrays. Chromatosomes can undergo a reversible chiral transition toward a state of positive torsion (reverse chromatosome) without loss of linker histones.
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Registered trials
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