ArticleBiophysical journal2011
DC-SIGN and influenza hemagglutinin dynamics in plasma membrane microdomains are markedly different.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Celebrating the creative scientific life of Ken Jacobson.Biophysical journal · 2023Article
- X-ray-Based Techniques to Study the Nano-Bio Interface.ACS nano · 2021Article
- Entry of Phenuiviruses into Mammalian Host Cells.Viruses · 2021Review
- Dectin-1-Mediated DC-SIGN Recruitment toLife (Basel, Switzerland) · 2021Article
- Quantitative Particle Uptake by Cells as Analyzed by Different Methods.Angewandte Chemie (International ed. in English) · 2020Review
- Rapid, directed transport of DC-SIGN clusters in the plasma membrane.Science advances · 2017Article
- N-glycan mediated adhesion strengthening during pathogen-receptor binding revealed by cell-cell force spectroscopy.Scientific reports · 2017Article
- The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile.Journal of nanobiotechnology · 2017Article
- Beyond attachment: Roles of DC-SIGN in dengue virus infection.Traffic (Copenhagen, Denmark) · 2017Article
- Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies.Nature communications · 2016Article
- Conjugation of Polymer-Coated Gold Nanoparticles with Antibodies-Synthesis and Characterization.Nanomaterials (Basel, Switzerland) · 2015Article
- Nanoclustering as a dominant feature of plasma membrane organization.Journal of cell science · 2014Review
- Stable small quantum dots for synaptic receptor tracking on live neurons.Angewandte Chemie (International ed. in English) · 2014Article
- Super-resolution imaging of C-type lectin spatial rearrangement within the dendritic cell plasma membrane at fungal microbe contact sites.Frontiers in physics · 2014Article
- Enhanced receptor-clathrin interactions induced by N-glycan-mediated membrane micropatterning.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A new tool to quantify receptor recruitment to cell contact sites during host-pathogen interaction.PLoS computational biology · 2014Article
- Low copy numbers of DC-SIGN in cell membrane microdomains: implications for structure and function.Traffic (Copenhagen, Denmark) · 2014Article
- The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells.The Journal of biological chemistry · 2012Article
- The formation and stability of DC-SIGN microdomains require its extracellular moiety.Traffic (Copenhagen, Denmark) · 2012Article
- Super-resolution imaging of C-type lectin and influenza hemagglutinin nanodomains on plasma membranes using blink microscopy.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
DC-SIGN, a Ca(2+)-dependent transmembrane lectin, is found assembled in microdomains on the plasma membranes of dendritic cells. These microdomains bind a large variety of pathogens and facilitate their uptake for subsequent antigen presentation. In this study, DC-SIGN dynamics in microdomains were explored with several fluorescence microscopy methods and compared with dynamics for influenza hemagglutinin (HA), which is also found in plasma membrane microdomains. Fluorescence imaging indicated that DC-SIGN microdomains may contain other C-type lectins and that the DC-SIGN cytoplasmic region is not required for microdomain formation. Fluorescence recovery after photobleaching measurements showed that neither full-length nor cytoplasmically truncated DC-SIGN in microdomains appreciably exchanged with like molecules in other microdomains and the membrane surround, whereas HA in microdomains exchanged almost completely. Line-scan fluorescence correlation spectroscopy indicated an essentially undetectable lateral mobility for DC-SIGN but an appreciable mobility for HA within their respective domains. Single-particle tracking with defined-valency quantum dots confirmed that HA has significant mobility within microdomains, whereas DC-SIGN does not. By contrast, fluorescence recovery after photobleaching indicated that inner leaflet lipids are able to move through DC-SIGN microdomains. The surprising stability of DC-SIGN microdomains may reflect structural features that enhance pathogen uptake either by providing high-avidity platforms and/or by protecting against rapid microdomain endocytosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.